Results 111 to 120 of about 2,639,603 (318)

Demographic features, clinical characteristics, and comorbid relation in hidradenitis suppurativa: a population-based study

Frontiers in Medicine
Background/objectiveHidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland areas, characterized by painful nodules and abscesses that may result in sinus tracts and scarring. The global prevalence of HS is increasing due
Gökhan Kaya, Fatma Pelin Özgen, Osman Kelahmetoğlu, Özlem Su Küçük, Nahide Onsun   +4 more
doaj   +1 more source

Toll-Like Receptor 4 Polymorphisms (896A/G and 1196C/T) as an Indicator of COVID-19 Severity in a Convenience Sample of Egyptian Patients

Journal of Inflammation Research, 2021
Sara I Taha,1 Aalaa K Shata,2 Shereen A Baioumy,3 Shaimaa H Fouad,4 Sherif G Anis,5 Isis M Mossad,6 Nouran M Moustafa,7,8 Dina M Abdou,9 Mariam K Youssef1 1Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt ...
Taha SI, Shata AK, Baioumy SA, Fouad SH, Anis SG, Mossad IM, Moustafa NM, Abdou DM, Youssef MK   +8 more
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Modeling catastrophe claims with left-truncated severity distributions (extended version) [PDF]

In this paper, we present a procedure for consistent estimation of the severity and frequency distributions based on incomplete insurance data and demonstrate that ignoring the thresholds leads to a serious underestimation of the ruin probabilities.
Rafal Weron, Stefan Trueck, Svetlozar Rachev, Anna Chernobai, Krzysztof Burnecki   +4 more
core  

ASSOCIATION OF DIFFERENT PARAMETERS OF COMPLETE BLOOD COUNT WITH SEVERITY AND PROGNOSIS OF GUILLAIN-BARRE SYNDROME

Pakistan Armed Forces Medical Journal, 2021
Objective: Guillain-barré syndrome is the most common and most severe acute paralytic neuropathy. This study is also aimed at to know that if there is any association of parameters of complete blood count and whether these can be used as a prognostic ...
Nauman Aziz, Humera Khan, Syeda Rizwana Jafri, Fauzia Qureshi, Amna Muneeb, Ursula Akif   +5 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The systemic immune-inflammation index is significantly associated with the severity of silicosis: a 9-year retrospective study in Beijing

Frontiers in Medicine
BackgroundSilicosis shows an increasing trend with the development of new industries. However, the potential biomarkers for predicting the disease severity are lacking.
Han-Yu-Jie Kang, Si-Yu Cao, Shuai Shao, Li-Rong Liang, Zhao-Hui Tong   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exploring motorcyclist injury severity in approach-turn collisions at T-junctions: Focusing on the effects of driver's failure to yield and junction control measures

, 2008
Research has suggested that motorcyclists involved in approach-turn crashes were much more injurious than any other crash-type. This paper investigates the determinants of motorcyclist injury severity resulting from such crash types that occurred at T ...
Pai, Chih-Wei, Saleh, Wafaa
core   +1 more source

Hypertriglyceridemia-Induced Acute Pancreatitis—The Milky Way Constellation—The Seven-Year Experience of a Large Tertiary Centre

Diagnostics
(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate ...
Andrei Vicențiu Edu, Mihai Radu Pahomeanu, Andreea Irina Ghiță, Dalia Ioana Constantinescu, Daniela Gabriela Grigore, Andreea Daniela Bota, Daniela Maria Luta-Dumitrașcu, Cristian George Țieranu, Lucian Negreanu   +8 more
doaj   +1 more source