Results 101 to 110 of about 2,937,854 (253)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Association between pain severity, depression severity, and use of health care services in Japan: results of a nationwide survey

, 2015
Jeffrey Vietri,1 Tempei Otsubo,2 William Montgomery,3 Toshinaga Tsuji,4 Eiji Harada5 1Health Outcomes Practice, Kantar Health, Milan, Italy; 2Tokyo Shinjuku Medical Center, Tokyo, Japan; 3Eli Lilly Australia Pty Ltd., West Ryde, Australia; 4Medical ...
Tsuji T, Otsubo T, Harada E, Vietri J, Montgomery W   +4 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modeling catastrophe claims with left-truncated severity distributions (extended version) [PDF]

In this paper, we present a procedure for consistent estimation of the severity and frequency distributions based on incomplete insurance data and demonstrate that ignoring the thresholds leads to a serious underestimation of the ruin probabilities.
Rafal Weron, Stefan Trueck, Svetlozar Rachev, Anna Chernobai, Krzysztof Burnecki   +4 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus

Frontiers in Virology
A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using
Moufid Mhamadi, Moufid Mhamadi, Ousseynou Sene, Arfang Diamanka, Moundhir Mhamadi, Marie Pedapa Mendy, Andy Mahine Diouf, Mignane Ndiaye, Mamadou Aliou Barry, Samba Niang Sagne, Mahfouz Cissé Traoré, Amadou Alpha Sall, Gamou Fall, Ndongo Dia, Oumar Faye   +14 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A clinical study correlating the serum levels of lactate dehydrogenase, C-reactive protein, and lipase with the severity and related complications of acute pancreatitis

Muller Journal of Medical Sciences and Research
Background: In addition to Ranson’s criteria, computed tomography severity index (CTSI), and Acute Physiology and Chronic Health Evaluation II score, the presence of local or systemic complications can predict severe acute pancreatitis (AP).
Partha Chakraborty, Sasanka Nath, Pankaj Kumar Halder, Dhiman Kumar Nayak, Suparna Halder, Arun Kumar Gupta   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Predictive Value of Lysophosphatidylcholine for Determining the Disease Severity and Prognosis of Elderly Patients with Community-Acquired Pneumonia

Clinical Interventions in Aging
Minghao Gu,1,2 SenSen Lv,1 Yihui Song,3 Hong Wang,4 Xingyu Zhang,5 Jing Liu,1 Deshun Liu,1 Xiudi Han,1 Xuedong Liu1 1Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China; 2School of
Gu M, Lv S, Song Y, Wang H, Zhang X, Liu J, Liu D, Han X, Liu X   +8 more
doaj