Results 51 to 60 of about 2,639,603 (318)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Assessment of the severity of atopic dermatitis [PDF]

, 2016
Atopic dermatitis is a frequent, chronic and recurrent inflammatory skin disease with complex etiology. Typical symptoms of this disease are persistent itching and dry skin.
Adam Reich, Agnieszka Bożek
core   +1 more source

Nomophobia: Prevalence and severity among Indian medical students – A systematic review and meta-analysis

Indian Journal of Psychiatry
Background: A growing dependence on smartphones for social interactions and learning has raised concerns about the psychological consequences of excessive usage, and nomophobia is one such concern. Aim: This review study and meta-analysis aimed to assess
Shiv K. Mudgal, Pratima Gupta, Rakhi Gaur, Saurabh Varshney, Vipin Patidar   +4 more
doaj   +1 more source

Study of correlation between bone mineral density and clinical and laboratory indices of rheumatoid arthritis activity

Научно-практическая ревматология, 2005
Objective. To study association between bone mineral density (BMD) and clinical and laboratory indices of rheumatoid arthritis (RA) activity Material and methods.
D. A. Gukasyan, R M Balabanova, A V Smirnov, E. L. Nassonov   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Severity-stratified diagnostic markers in relation to symptom and total disease days.

Four diagnostic markers (systolic blood pressure, pulse, haemoglobin (Hb) and haematocrit (HCT)) show different correlations with pre-hospitalisation symptom days with little difference between disease severity scores 1 and 2.
Wim A. Fleischmann (17873822), Nguyen Trong The (17873837), Mario Recker (88496), Nguyen Viet Hoang (17873843), Thirumalaisamy P. Velavan (10128014), Le Van Nam (17873831), Trinh Huu Nghia (17873825), Nhat My Truong (10575875), Nguyen Linh Toan (14071894), Peter G. Kremsner (9080245), Le Huu Song (11386339), Do Duc Anh (17873834), Nguyen Van Truong (17873828), Chu Xuan Anh (17873840)   +13 more
core   +2 more sources

Behсet's disease: clinical and gender associations

Современная ревматология, 2019
Objective: to compare the frequency of clinical manifestations of Behcet's disease (BD) in patients of both sexes in a Russian cohort.Patients and methods.
Z. S. Alekberova, T. A. Lisitsyna, R. G. Goloeva, G. A. Davydova   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study

Frontiers in Medicine
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood ...
Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M. Becker, Alison D. Augustine, Al Ozonoff, Leying Guan, Steven H. Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R. Langelier, Holden Maecker, Seunghee Kim, Ruth R. Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E. Bosinger, Ofer Levy, Hanno Steen, Lindsey B. Rosen, Lindsey R. Baden, Esther Melamed, Lauren I. R. Ehrlich, Grace A. McComsey, Rafick P. Sekaly, Joanna Schaenman, Albert C. Shaw, David A. Hafler, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S. Calfee, David J. Erle, IMPACC Network, Lucy F. Robinson, Charles B. Cairns, Elias K. Haddad, Mary Ann Comunale   +53 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source