Results 61 to 70 of about 2,639,603 (318)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The accuracy of the Learning Disability Screening Questionnaire (LDSQ) in classifying severity of impairment: A brief report

, 2014
Background: Outcomes for people with an intellectual disability (ID) may differ depending on the severity of the condition. This study evaluated whether a tool used to screen for the presence of ID could also give an early indication of severity, in ...
Murray, Aja Louise, McKenzie, Karen
core   +1 more source

Unravelling during cold storage and shelf life the pathological and physicochemical characteristics of postharvest apples and oranges

Frontiers in Horticulture
Fruits are susceptible to a diverse range of postharvest rots, which can reduce quality if preventive measures are not taken in time. In this study, samples of orange cv. Maltaise and apple cvs. Golden Delicious and Richared were sorted without infection
Mohamed Bechir Allagui, Mouna Ben Amara
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mixed-severity fire regimes: Lessons and hypotheses from the Klamath-Siskiyou Ecoregion

, 2011
Although mixed-severity fires are among the most widespread disturbances influencing western North American forests, they remain the least understood.
Kayes, L.J., Hibbs, D.E., Campbell, J.L., Donaghy Cannon, M., Donato, D.C., Bormann, B.T., Spies, T.A., Fontaine, J.B., Halofsky, J.E., Law, B.E., Peterson, D.L., Thompson, J.R., Anthony, R.G.   +12 more
core  

Classification of asthma severity: Severe/not severe asthma or mild/moderate/severe asthma?

Tuberk Toraks, 2022
İnsu Yılmaz, Gülden Paçacı Çetin, Bahar Arslan   +2 more
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source