Results 131 to 140 of about 2,913,878 (328)

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

A Severity of Illness Index and Health-Related Quality of Life for Teens with Congenital Heart Disease [PDF]

, 1999
Marlene R. Miller, Jean S. Kan, Christopher B. Forrest   +2 more
openalex   +1 more source

Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker

Advanced Science, EarlyView.
The study detects a potential multimodal biomarker that can be promising for identifying early markers of psychosis. It shows a consistent brain‐behavior association between a circuit of interconnected regions and executive function in neurotypical controls and individuals at various stages of psychosis.
Leonardo Fazio, Giuseppe Stolfa, Roberta Passiatore, Angelantonio Tavella, Giuseppe Blasi, Madalina O. Buciuman, Aaron L. Goldman, Shalaila S. Haas, Lana Kambeitz‐Ilankovic, Nikolaos Koutsouleris, Monica Nicoli, Teresa Popolizio, Antonio Rampino, Anne Ruef, Fabio Sambataro, Pierluigi Selvaggi, William Ulrich, Daniel R. Weinberger, Apulian Network on Risk for Psychosis, PRONIA Consortium, Alessandro Bertolino, Linda A. Antonucci, Giulio Pergola   +22 more
wiley   +1 more source

Sharp well-posedness and ill-posedness of the Navier-Stokes initial value problem in Besov-type spaces [PDF]

arXiv, 2015
We prove that the Navier-Stokes initial value problem is well-posed in the logrithmically refined Besov spaces when the second index is not less than certain critical value, and ill-posed in such spaces when the second index is less than this critical value.
arxiv  

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

Advanced Science, EarlyView.
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa, Jiali Wang, Mengzhao Xun, Jessica M. Rosenholm, Wuqing Wang, Yilai Shu, Hongbo Zhang   +6 more
wiley   +1 more source

Some Results on Regularization of LSQR and CGLS for Large-Scale Discrete Ill-Posed Problems [PDF]

arXiv, 2014
For large-scale discrete ill-posed problems, LSQR, a Lanczos bidiagonalization process based Krylov method, is most often used. It is well known that LSQR has natural regularizing properties, where the number of iterations plays the role of the regularization parameter.
arxiv  

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Prognostic Nutritional Index (PNI) and Systemic Immune-Inflammatory Index (SII) as markers of severity among patients having COVID-19 infection

Journal of Family Medicine and Primary Care
Background: Prognostic nutritional index (PNI) and systemic immune-inflammatory index (SII) are two novel markers that have emerged as potential candidates as an early indication of the severity of the disease in coronavirus disease 2019 (COVID-19 ...
Rithika Manjunatha Reddy, Sana Suthana, Aditya Karthikeyan, Ashwin Kulkarni, Shaikh Mohammed Aslam, K Mohammed Suhail   +5 more
doaj   +1 more source

Correction: Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study

, 2021
Cristian Aragón‐Benedí, Pablo Oliver-Forniés, Felice Galluccio, Ece Yamak Altınpulluk, Tolga Ergönenç, Abdallah El-Sayed Allam, Carlos Salazar, Mario Fajardo‐Pérez   +7 more
openalex   +2 more sources

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source