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The Distribution of Sevoflurane in a Sevoflurane Induced Death
Journal of Forensic Sciences, 2004Abstract The distribution of sevoflurane (fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl) ethyl ether) in blood, urine, liver, kidney, vitreous humor, and tracheal aspirate is presented from a subject with a sevoflurane induced death.
Burrows, David L. +3 more
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TOXICITY OF SEVOFLURANE IN RATS
Anesthesia & Analgesia, 1987Sevoflurane, an experimental potent volatile anesthetic with a low blood/gas partition coefficient, degrades in the presence of soda lime to products the toxicity of which is unknown. We tested whether toxic products were produced by the passage of sevoflurane through soda lime, and a comparison was made of the toxicity of sevoflurane passed through ...
Brynte H. Johnson +4 more
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Biotransformation of Sevoflurane
Anesthesia & Analgesia, 1995Several characteristics of sevoflurane biotransformation are apparent from the preceding investigations. Metabolism is rapid, with fluoride and HFIP appearing in plasma within minutes after the start of sevoflurane administration (38-40,51). Peak plasma fluoride concentrations generally occur within approximately 1 h after the termination of ...
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Clinical Pharmacokinetics of Sevoflurane
Clinical Pharmacokinetics, 1999Sevoflurane is a comparatively recent addition to the range of inhalational anaesthetics which has been recently released for clinical use. In comparison to older inhalational agents such as isoflurane or halothane, the most important property of sevoflurane is its low solubility in the blood. This results in a more rapid uptake and induction than the '
Hans-Joachim Wilke +2 more
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Subarachnoid hemorrhage and sevoflurane
Turkish Neurosurgery, 2018To examine whether post-treatment sevoflurane is protective against early brain injury (EBI) after subarachnoid hemorrhage (SAH) and how this neuroprotective effect occurs at different concentrations and durations of administration in mice. Furthermore, we tested whether the neuroprotective effect of post-treatment sevoflurane is associated with ...
Orhan Altay, Mehmet Sorar
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Toxicology Letters, 2014
This study aimed to correlate environmental sevoflurane levels with urinary concentrations of sevoflurane (Sev-U) or its metabolite hexafluoroisopropanol (HFIP) in order to assess and discuss the main issues relating to which biomarker of sevoflurane exposure is best, and possibly suggest the corresponding biological equivalent exposure limit values ...
Maria Luisa Scapellato +6 more
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This study aimed to correlate environmental sevoflurane levels with urinary concentrations of sevoflurane (Sev-U) or its metabolite hexafluoroisopropanol (HFIP) in order to assess and discuss the main issues relating to which biomarker of sevoflurane exposure is best, and possibly suggest the corresponding biological equivalent exposure limit values ...
Maria Luisa Scapellato +6 more
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Sevofluran: Metabolismus und Toxizität
Der Anaesthesist, 1998The new inhalational anesthetic sevoflurane is biotransformed by approximately 5%. Serum fluoride concentrations resulting from transformation mainly depend on rate of hepatic defluorination, total amount of anesthetic given and the solubility of the volatile anesthetic, as expressed by its blood gas partition coefficient. Enflurane is metabolized by 5-
Peter Conzen, M Nuscheler, Klaus Peter
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Clinical Sevoflurane Metabolism and Disposition
Survey of Anesthesiology, 1995Background Sevoflurane has low blood and tissue solubility and is metabolized to free fluoride and hexafluoroisopropanol (HFIP). Although sevoflurane uptake and distribution and fluoride formation have been described, the pharmacokinetics of HFIP formation and elimination are incompletely understood.
Michael D. Karol +3 more
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