Results 121 to 130 of about 4,240,671 (271)

RET is a sex-biased regulator of intestinal tumorigenesis

Frontiers in Gastroenterology
Ret is implicated in colorectal cancer (CRC) as both a proto-oncogene and a tumor suppressor. We asked whether RET signaling regulates tumorigenesis in an Apc-deficient preclinical model of CRC.
Sean T. Koester, Sean T. Koester, Naisi Li, Neelendu Dey, Neelendu Dey, Neelendu Dey   +5 more
doaj   +1 more source

Code and data from Genetic constraints on microevolutionary divergence of sex-biased gene expression

, 2018
The evolution of sex-specific phenotypes is an important dimension of diversification and local adaptation. The sex-dependent regulation of gene expression is considered a key genomic mechanism facilitating sex-dependent adaptation.
Stephen F. Chenoweth (265642), Russell Bonduriansky (2276881), Scott L. Allen (3242856)   +2 more
core   +1 more source

Tissue Specificity and Dynamics of Sex-Biased Gene Expression in a Common Frog Population with Differentiated, Yet Homomorphic, Sex Chromosomes [PDF]

, 2018
Sex-biased genes are central to the study of sexual selection, sexual antagonism, and sex chromosome evolution. We describe a comprehensive de novo assembled transcriptome in the common frog Rana temporaria based on five developmental stages and three ...
Perrin, N., Rodrigues, N., Sermier, R., Wen-Juan Ma, Melissa Toups, Rodrigues, Nicolas, Veltsos, P., Toups, Melissa A ; https://orcid.org/, Nicolas Rodrigues, Daniel L. Jeffries, Toups, M.A., Sermier, Roberto, Roberto Sermier, Daniel Jeffries, Nicolas Perrin, Perrin, Nicolas, Veltsos, Paris, Jeffries, Daniel, Ma, W.J., Jeffries, D.L., Ma, Wen, Melissa A. Toups, Paris Veltsos, Rodrigues N, Ma WJ, Perrin N, Jeffries DL, Toups MA, Veltsos P, Sermier R   +29 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

The developmental origins of sex-biased expression in cardiac development

Biology of Sex Differences, 2019
Background Expression patterns between males and females vary in every adult tissue, even in organs with no conspicuous dimorphisms such as the heart.
Daniel F. Deegan, Reza Karbalaei, Jozef Madzo, Rob J. Kulathinal, Nora Engel   +4 more
doaj   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Mating system manipulation and the evolution of sex-biased gene expression in Drosophila [PDF]

, 2017
Funding: Natural Environment Research Council grant (NE/I014632/1) to MGR, RRS & ARC, and an associated NBAF award (NBAF654).Sex differences in dioecious animals are pervasive and result from gene expression differences.
Snook, Rhonda R., Andrew R. Cossins, Snook, R.R., Cossins, Andrew R, Cossins, Andrew R., Veltsos, P., Fang, Yongxiang, Ritchie, Michael G, Rhonda R. Snook, Ritchie, M.G., Veltsos, Paris, Ritchie, Michael Gordon, Snook, Rhonda R, Yongxiang Fang, Ritchie, Michael G., Michael G. Ritchie, Snook, Rhonda R.,, Paris Veltsos, Fang, Y., Cossins, A.R., Ritchie, Michael Gordon; id_orcid   +20 more
core   +1 more source