Exploring sex bias in cardiometabolic diseases [PDF]
Lipids in Health and DiseaseCardiometabolic diseases (CMDs), such as cardiovascular diseases (CVDs), obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH), represent an alarming burden on healthcare systems. Differences in the prevalence, progression
Tania Guillemette +3 more
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Sex bias in lymphocytes: Implications for autoimmune diseases [PDF]
Frontiers in Immunology, 2022 Autoimmune diseases are characterized by a significant sex dimorphism, with women showing increased susceptibility to disease. This is, at least in part, due to sex-dependent differences in the immune system that are influenced by the complex interplay ...
Katherine C. Dodd +2 more
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Sex bias consideration in healthcare machine-learning research: a systematic review in rheumatoid arthritis [PDF]
BMJ OpenObjective To assess the acknowledgement and mitigation of sex bias within studies using supervised machine learning (ML) for improving clinical outcomes in rheumatoid arthritis (RA).Design A systematic review of original studies published in English ...
Coziana Ciurtin +7 more
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The impact of age on sex bias in models for height and sex estimation based on hand and foot dimensions the impact of age on sex bias [PDF]
Heliyon, 2023 There are sex differences in age-related bone modifications after puberty. Androgens stimulate radial bone expansion in males, while estrogen stimulates endosteal apposition but limits periosteal expansion in females.
Moses Banyeh +2 more
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Relating sex-bias in human cortical and hippocampal microstructure to sex hormones [PDF]
Nature CommunicationsDetermining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment of brain-related disorders. So far, studies on sex-bias in brain structure predominantly focus on macro-scale measures, and often ignore factors ...
Svenja Küchenhoff +9 more
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Location and timing of infection drives a sex-bias in Haemoproteus prevalence in a hole-nesting bird [PDF]
ParasitologySex biases in prevalence of disease are often attributed to intrinsic factors, such as physiological differences while a proximate role of extrinsic factors such as behavioural or ecological differences may be more difficult to establish.
William Jones +2 more
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The Sex Inclusive Research Framework to address sex bias in preclinical research proposals [PDF]
Nature CommunicationsAn interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research.
Natasha A. Karp +16 more
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Sex Bias in Autoimmunity: New Findings and New Opportunities [PDF]
JID InnovationsAutoimmune diseases result from the immune system’s inability to discriminate between self and foreign antigens, leading to development of self-reactive immune cells and autoantibodies that can cause organ damage and failure.
Vincent van Drongelen +2 more
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Sex bias in prospective follow-up observational studies with drugs carried out in a southern region of Europe [PDF]
Frontiers in PharmacologyIntroductionThe impact of sex bias in medical research is a matter of significant relevance and importance especially in the modern age. Despite notable improvements in sex equity across various societal fields, disparities in sex representation persist ...
Àlex Santomà +8 more
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Male Sex Bias in Immune Biomarkers for Tuberculosis
Frontiers in Immunology, 2021 Males have a bias toward developing sputum smear-positive pulmonary tuberculosis, whereas other forms of the disease have an equal sex ratio. Immune responses are known to be affected by estrogen and testosterone.
Graham H. Bothamley +2 more
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