Results 81 to 90 of about 31,435,271 (262)

High‐mobility‐group protein 2 regulated by microRNA‐127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells

Hepatology Communications, 2017
High‐mobility‐group protein 2 (HMGB2) expression is up‐regulated in human liver cancer; however, little is known about its regulatory function. Here, we establish HMGB2 as a new modulator of the pluripotency of mouse embryonic stem cells.
Yulan Zhao, Zhihong Yang, Jianguo Wu, Raymond Wu, Santosh K. Keshipeddy, Dennis Wright, Li Wang   +6 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Molecular sexing of brown lemming remains

Arctic Science
Accurate sex identification of prey remains can provide valuable insights into selective predation, but field studies are often constrained by degraded or digested material.
Camille Gaudreau-R., Glenn Yannic, Dominique Fauteux, Jenna Benson, Sara Gillespie, David Paetkau, Pierre Legagneux   +6 more
doaj   +1 more source

Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes

Animals, 2019
Copy number variation (CNV), a significant source of genetic diversity in the mammalian Y chromosome, is associated with the development of many complex phenotypes, such as spermatogenesis and male fertility.
Ting Sun, Quratulain Hanif, Hong Chen, Chuzhao Lei, Ruihua Dang   +4 more
doaj   +1 more source

The Sex Determining Loci and Sex Chromosomes in the Family Salmonidae [PDF]

, 2009
Post-printSalmonids are descended from a common ancestor that underwent an autotetraploidization event. After a whole genome duplication species could deal with sex determination by deleting one copy of SEX, the sex determining locus, or by recruiting a ...
Davidson, W.S., Fujiki, T.-K., von Schalburg, K.R., Huang, K., Koop, B.F.   +4 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

IRF4 contributes to chemoresistance in IGH::BCL2‐positive diffuse large B‐cell lymphomas by mediating BCL2‐induced SOX9 expression

Clinical and Translational Medicine
Background Diffuse large B‐cell lymphoma (DLBCL), an aggressive type of non‐Hodgkin's lymphoma, has a high relapse/refractory rate. We previously identified sex‐determining region Y (SRY)‐box transcription factor (SOX9) as a transcription factor that ...
Yirong Zhang, Zizhen Xu, Ruixin Sun, Yixuan Gao, Innocent Agida, Kasimujiang Aximujiang, Lin Yuan, Jiao Ma   +7 more
doaj   +1 more source

The sex locus is tightly linked to factors conferring sex-specific lethal effects in the mosquito Aedes aegypti [PDF]

, 2016
In many taxa, sex chromosomes are heteromorphic and largely non-recombining. Evolutionary models predict that spread of recombination suppression on the Y chromosome is fueled by the accumulation of sexually antagonistic alleles in close linkage to the ...
de la Casa-Esperon, E, Kokoza, V, A S Raikhel, Krzywinska, E, M Morris, Krzywinski, J, Kokoza, V., Raikhel, AS, Morris, Marion, De La Casa-Esperon, E., Krzywinska, E., J Krzywinski, E Krzywinska, Morris, M, V Kokoza, Raikhel, A. S., E de la Casa-Esperon, Krzywinski, J.   +17 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source