Results 61 to 70 of about 29,265,468 (278)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of the role of the X/Y homologous gene family Xmr/Sly in murine spermiogenesis [PDF]

, 2009
Spermatogenesis is a complex, continuous developmental process that involves the formation of highly differentiated haploid sperm from diploid spermatogonial stem cells.
Reynard, L N, Reynard, L.N.
core  

Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation. [PDF]

, 2010
The human and mouse sex chromosomes are enriched in multicopy genes required for postmeiotic differentiation of round spermatids into sperm. The gene Sly is present in multiple copies on the mouse Y chromosome and encodes a protein that is required for ...
Ojarikre, Obah A., Burgoyne, Paul S, Yamauchi, Yasuhiro, Rattigan, Aine, Julie Cocquet, Jonathan M. Riel, Thomas P. S. Karacs, Áine Rattigan, Yasuhiro Yamauchi, Riel, Jonathan M., Cocquet, Julie, Affara, Nabeel A., Monika A. Ward, Paul S. Burgoyne, Karacs, Thomas P.S., Ellis, Peter J.I., Obah A. Ojarikre, Peter J. I. Ellis, Nabeel A. Affara, Ward, Monika A.   +19 more
core   +1 more source

Characterization of the OmyY1 Region on the Rainbow Trout Y Chromosome

International Journal of Genomics, 2013
We characterized the male-specific region on the Y chromosome of rainbow trout, which contains both sdY (the sex-determining gene) and the male-specific genetic marker, OmyY1.
Ruth B. Phillips, Jenefer J. DeKoning, Joseph P. Brunelli, Joshua J. Faber-Hammond, John D. Hansen, Kris A. Christensen, Suzy C. P. Renn, Gary H. Thorgaard   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Experimental tests of sex allocation theory in a simultaneous hermaphrodite using phenotypic engineering [PDF]

, 2014
Sex allocation theory can provide successful predictions about how individuals allocate resources into male and female reproduction. However, in simultaneous hermaphrodites, experimental support for some fundamental aspects of sex allocation theory are ...
Sekii, Kiyono
core   +1 more source

Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway

, 2022
Breast cancer is the most frequent cancer among women and the second highest mortality in female across the world. Recent studies have illustrated that sex-determining region Y (SRY)-box protein (SOX) family plays essential roles in regulating various ...
Wenyang Pang (12631998), Jian Huang (7250), Zhengyi Wang (190546), Xiaoyan Jin (1785316), Xuan Shao (5570414)   +4 more
core   +1 more source

Impact of SOX2 function and regulation on therapy resistance in bladder cancer

Frontiers in Oncology, 2022
Bladder cancer (BC) is a malignant disease with high rates of recurrence and mortality. It is mainly classified as non-muscle-invasive BC and muscle-invasive BC (MIBC).
Guodong Chen, Guodong Chen, Guodong Chen, Yan Chen, Ruiquan Xu, Ruiquan Xu, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Gengqing Wu, Gengqing Wu   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

YBX1 (Y box binding protein 1) [PDF]

, 2011
Review on YBX1 (Y box binding protein 1), with data on DNA, on the protein encoded, and where the gene is ...
Sorokin, A, Evdokimova, V
core   +1 more source