Results 51 to 60 of about 29,265,468 (278)

A family case of fertile human 45,X,psu dic(15;Y) males [PDF]

, 2006
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
P.M. Gopinath, Hansmann, Ingo, I. Hansmann, Schempp, Werner, Wimmer, R., Palaniappan, I., Wimmer, Rainer, W. Schempp, I. Palaniappan, Palaniappan, Ilayaraja, Gopinath, P. M., N. Chandra, Hansmann, I., Chandra, N., Nagarajappa, C. S., R. Wimmer, C.S. Nagarajappa, Schempp, W.   +17 more
core   +1 more source

Deep ancestry of mammalian X chromosome revealed by comparison with the basal tetrapod Xenopus tropicalis

BMC Genomics, 2012
Background The X and Y sex chromosomes are conspicuous features of placental mammal genomes. Mammalian sex chromosomes arose from an ordinary pair of autosomes after the proto-Y acquired a male-determining gene and degenerated due to suppression of X-Y ...
Mácha Jaroslav, Teichmanová Radka, Sater Amy K, Wells Dan E, Tlapáková Tereza, Zimmerman Lyle B, Krylov Vladimír   +6 more
doaj   +1 more source

The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer

Biomedicines, 2023
Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visfatin, a novel adipokine highly expressed in cancer patients, is related to breast cancer risk.
Yi-Fen Chiang, Ko-Chieh Huang, Hsin-Yuan Chen, Tsui-Chin Huang, Mohamed Ali, Hsin-Yi Chang, Tzong-Ming Shieh, Yin-Hwa Shih, Kai-Lee Wang, Yun-Ju Huang, Cheng-Pei Chung, Shih-Min Hsia   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Temperature-dependent sex determination in fish revisited: Prevalence a single sex ratio response pattern, and possible effects of climate change. [PDF]

, 2008
Ospina-Álvarez N, Piferrer F (2008) Temperature-Dependent Sex Determination in Fish Revisited: Prevalence, a Single Sex Ratio Response Pattern, and Possible Effects of Climate Change. PLoS ONE 3(7): e2837.
Piferrer, Francesc, Natalia Ospina-Alvarez, Francesc Piferrer, Ospina-Álvarez Natalia, Piferrer Francesc, Piferrer, F., Ospina-Álvarez, Natalia, Ospina-Alvarez, N.   +7 more
core   +2 more sources

Evolution of the sex-determining region in Ginkgo biloba [PDF]

, 2022
Sex chromosomes or sex-determining regions (SDR) have been discovered in many dioecious plant species, including the iconic 'living fossil' Ginkgo biloba, though the location and size of the SDR in G. biloba remain contradictory.
Filatov, Dmitry, Gong, Wei
core   +1 more source

Characterization of Schistosome Sox Genes and Identification of a Flatworm Class of Sox Regulators

Pathogens, 2023
Schistosome helminths infect over 200 million people across 78 countries and are responsible for nearly 300,000 deaths annually. However, our understanding of basic genetic pathways crucial for schistosome development is limited.
Stephanie Wood, Kenji Ishida, James R. Hagerty, Anida Karahodza, Janay N. Dennis, Emmitt R. Jolly   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A SRY-HMG box frame shift mutation inherited from a mosaic father with a mild form of testicular dysgenesis syndrome in Turner syndrome patient

BMC Medical Genetics, 2010
Background Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in development of testicular tissue.
Batra Swaraj, Haque Shameemul, Khalil Hesham, Dhillon Varinderpal S, Shahid Mohammad, Husain Syed, Looijenga LHJ   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source