Formation of the Embryonic Organizer Is Restricted by the Competitive Influences of Fgf Signaling and the SoxB1 Transcription Factors [PDF]
PLoS ONE, 2013 The organizer is one of the earliest structures to be established during vertebrate development and is crucial to subsequent patterning of the embryo. We have previously shown that the SoxB1 transcription factor, Sox3, plays a central role as a transcriptional repressor of zebrafish organizer gene expression.
Jane E Hewitt, Paul J Scotting
exaly +8 more sources
Role of SoxB1 transcription factors in development [PDF]
Cellular and Molecular Life Sciences, 2009 SoxB1 factors, which include Sox1, 2, and 3, share more than 90% amino acid identity in their DNA binding HMG box and participate in diverse developmental events. They are known to exert cell-type-specific functions in concert with other transcription factors on Sox factor-dependent regulatory enhancers.
Satoru Miyagi +2 more
exaly +4 more sources
Development, 2023 ABSTRACT SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription
Elizabeth N. Schock +4 more
openaire +4 more sources
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation [PDF]
Development (Cambridge), 2008 The preservation of a pool of neural precursors is a prerequisite for proper establishment and maintenance of a functional central nervous system(CNS). Both Notch signaling and SoxB1 transcription factors have been ascribed key roles during this process, but whether these factors use common or distinct mechanisms to control progenitor maintenance is ...
Johan Holmberg, , Thomas Perlmann
exaly +3 more sources
Developmental Biology, 2018 Abstract The neural crest is a stem cell population unique to vertebrate embryos that gives rise to derivatives from multiple embryonic germ layers. The molecular underpinnings of potency that govern neural crest potential are highly conserved with that of pluripotent blastula stem cells, suggesting that neural crest cells may have ...
Elizabeth N Schock, Carole Labonne
exaly +4 more sources
SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling [PDF]
Development (Cambridge), 2010 Formation of the organizer is one of the most central patterning events in vertebrate development. Organizer-derived signals are responsible for establishing the CNS and patterning the dorsal ventral axis. The mechanisms promoting organizer formation are known to involve cooperation between Nodal and Wnt signalling.
Paul J Scotting
exaly +3 more sources
SoxB1-mediated chromatin remodeling promotes sensory neuron differentiation in planarians [PDF]
GeneticsSarai Alvarez Zepeda +2 more
exaly +2 more sources
Genome-wide identification, evolutionary diversification and developmental expression of the Sox gene family in three brachyuran crabs. [PDF]
BMC GenomicsChen D, Xie X, Bao C, Zhu D.
europepmc +1 more source
<i>Smed-pou4-2</i> regulates mechanosensory neuron regeneration and function in planarians. [PDF]
ElifeMcCubbin RA +7 more
europepmc +1 more source
Regulation of zygotic genome activation by the nucleocytoplasmic ratio. [PDF]
Front Cell Dev BiolAcker L, Chen H.
europepmc +1 more source