Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors. [PDF]
PLoS ONE, 2013 The organizer is one of the earliest structures to be established during vertebrate development and is crucial to subsequent patterning of the embryo.
Cheng-Liang Kuo +3 more
doaj +9 more sources
SoxB1 transcription factors are essential for initiating and maintaining neural plate border gene expression [PDF]
Development, 2023 ABSTRACT SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription
Elizabeth N. Schock +4 more
europepmc +5 more sources
SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling [PDF]
Development (Cambridge), 2010 Formation of the organizer is one of the most central patterning events in vertebrate development. Organizer-derived signals are responsible for establishing the CNS and patterning the dorsal ventral axis. The mechanisms promoting organizer formation are known to involve cooperation between Nodal and Wnt signalling.
Yu-Huan, Shih +6 more
exaly +4 more sources
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation [PDF]
Development (Cambridge), 2008 The preservation of a pool of neural precursors is a prerequisite for proper establishment and maintenance of a functional central nervous system(CNS). Both Notch signaling and SoxB1 transcription factors have been ascribed key roles during this process, but whether these factors use common or distinct mechanisms to control progenitor maintenance is ...
exaly +3 more sources
Developmental Biology, 2018 Abstract The neural crest is a stem cell population unique to vertebrate embryos that gives rise to derivatives from multiple embryonic germ layers. The molecular underpinnings of potency that govern neural crest potential are highly conserved with that of pluripotent blastula stem cells, suggesting that neural crest cells may have ...
Carole Labonne
exaly +4 more sources
Frontiers in NeuroscienceIntroductionThe remarkable diversity observed in the structure and development of the molluscan nervous system raises intriguing questions regarding the molecular mechanisms underlying neurogenesis in Mollusca. The expression of SoxB family transcription
Anastasia I. Kurtova +11 more
doaj +3 more sources
Dbx1 is a direct target of SOX3 in the spinal cord. [PDF]
PLoS ONE, 2014 SoxB1 sub-family of transcriptional regulators are expressed in progenitor (NP) cells throughout the neuroaxis and are generally downregulated during neuronal differentiation.
Nicholas Rogers +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 In vertebrates, the four transcription factors Sox2, c-Myc, Pou5f1 and Klf4 are involved in the differentiation of several tissues during vertebrate embryogenesis; moreover, they are normally co-expressed in embryonic stem cells and play roles in ...
Virginia Vanni +9 more
doaj +1 more source
Analyses of Sox-B and Sox-E Family Genes in the Cephalopod Sepia officinalis: Revealing the Conserved and the Unusual. [PDF]
PLoS ONE, 2016 Cephalopods provide an unprecedented opportunity for comparative studies of the developmental genetics of organ systems that are convergent with analogous vertebrate structures. The Sox-family of transcription factors is an important class of DNA-binding
Laura Focareta, Alison G Cole
doaj +1 more source
Involvement of ubiquitous and tale transcription factors, as well as liganded RXRα, in the regulation of human SOX2 gene expression in the NT2/D1 embryonal carcinoma cell line [PDF]
Archives of Biological Sciences, 2010 SOX2 is a key transcription factor in embryonic development representing a universal marker of pluripotent stem cells. Based on the functional redundancy and overlapping expression patterns of SOXB1 subgroup members during development, the goal of this ...
Milivojević Milena +6 more
doaj +1 more source