Results 1 to 10 of about 3,017 (76)

Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors. [PDF]

PLoS ONE, 2013
The organizer is one of the earliest structures to be established during vertebrate development and is crucial to subsequent patterning of the embryo.
Cheng-Liang Kuo, Chi Man Lam, Jane E Hewitt, Paul J Scotting   +3 more
doaj   +8 more sources

SoxB1 transcription factors are essential for initiating and maintaining neural plate border gene expression

Development (Cambridge), 2023
ABSTRACT SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription
Carole Labonne, Joshua York, Elizabeth Schock   +2 more
exaly   +5 more sources

Role of SoxB1 transcription factors in development [PDF]

Cellular and Molecular Life Sciences, 2009
SoxB1 factors, which include Sox1, 2, and 3, share more than 90% amino acid identity in their DNA binding HMG box and participate in diverse developmental events. They are known to exert cell-type-specific functions in concert with other transcription factors on Sox factor-dependent regulatory enhancers.
Akihiko Okuda, Satoru Miyagi, Okuda Akihiko   +2 more
exaly   +4 more sources

Early nervous system development in the chaetognath Spadella cephaloptera exhibits conserved bilaterian patterning features [PDF]

Frontiers in Cell and Developmental Biology
Nervous systems display extensive diversity in structure and organization, yet a broadly conserved set of signaling pathway components and transcription factors is consistently associated with early neurogenesis in many animal lineages.
June F. Ordoñez, June F. Ordoñez, Alice Frisinghelli, Alice Frisinghelli, Cristian Camilo Barrera Grijalba, Cristian Camilo Barrera Grijalba, Tim Wollesen   +6 more
doaj   +2 more sources

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation [PDF]

Development (Cambridge), 2008
The preservation of a pool of neural precursors is a prerequisite for proper establishment and maintenance of a functional central nervous system(CNS). Both Notch signaling and SoxB1 transcription factors have been ascribed key roles during this process, but whether these factors use common or distinct mechanisms to control progenitor maintenance is ...
, , Lendahl Urban
exaly   +3 more sources

A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells

Developmental Biology, 2018
Abstract The neural crest is a stem cell population unique to vertebrate embryos that gives rise to derivatives from multiple embryonic germ layers. The molecular underpinnings of potency that govern neural crest potential are highly conserved with that of pluripotent blastula stem cells, suggesting that neural crest cells may have ...
Carole Labonne
exaly   +4 more sources

Generation of Chimera-Competent Avian iPSCs Using Defined Transcription Factors [PDF]

Cells
iPSC technology is well established in mammals but remains underdeveloped in non-mammalian species. A major barrier to generating avian iPSCs has been the lack of species-specific reprogramming factors and culture conditions capable of supporting self ...
Xinyi Tong, Xi Chen, Arlene Anicete, Yanpui Chan, Xuan Zhou, Xizi Wang, Daniel B. McKim, Qi-Long Ying   +7 more
doaj   +2 more sources

SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling [PDF]

Development (Cambridge), 2010
Formation of the organizer is one of the most central patterning events in vertebrate development. Organizer-derived signals are responsible for establishing the CNS and patterning the dorsal ventral axis. The mechanisms promoting organizer formation are known to involve cooperation between Nodal and Wnt signalling.
Paul J Scotting, Scotting Paul J
exaly   +3 more sources

Identification and expression analysis of Sox family genes in echinoderms [PDF]

BMC Genomics
The Sox gene family, a collection of transcription factors widely distributed throughout the animal kingdom, plays a crucial role in numerous developmental processes.
Xiaojing Li, Tiangui Cao, Hui Liu, Longhai Fu, Quanchao Wang   +4 more
doaj   +2 more sources

Expanded expression of pro-neurogenic factor SoxB1 during larval development of gastropod Lymnaea stagnalis suggests preadaptation to prolonged neurogenesis in Mollusca

Frontiers in Neuroscience
IntroductionThe remarkable diversity observed in the structure and development of the molluscan nervous system raises intriguing questions regarding the molecular mechanisms underlying neurogenesis in Mollusca. The expression of SoxB family transcription
Anastasia I. Kurtova, Alexander D. Finoshin, Margarita S. Aparina, Margarita S. Aparina, Guzel R. Gazizova, Olga S. Kozlova, Svetlana N. Voronova, Elena I. Shagimardanova, Elena I. Shagimardanova, Elena I. Shagimardanova, Evgeny G. Ivashkin, Elena E. Voronezhskaya   +11 more
doaj   +3 more sources