Results 21 to 30 of about 2,990 (93)

A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian

eLife, 2022
Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their neural function evolved is unclear ...
Eleni Chrysostomou, Hakima Flici, Sebastian G Gornik, Miguel Salinas-Saavedra, James M Gahan, Emma T McMahon, Kerry Thompson, Shirley Hanley, Michelle Kilcoyne, Christine E Schnitzler, Paul Gonzalez, Andreas D Baxevanis, Uri Frank   +12 more
doaj   +1 more source

Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. [PDF]

PLoS ONE, 2014
SOX14 is a member of the SOXB2 subgroup of transcription factors implicated in neural development. Although the first SOX14 gene in vertebrates was cloned and characterized more than a decade ago and its expression profile during development was revealed
Jelena Popovic, Danijela Stanisavljevic, Marija Schwirtlich, Andrijana Klajn, Jelena Marjanovic, Milena Stevanovic   +5 more
doaj   +1 more source

Serum proteome profiling reveals SOX3 as a candidate prognostic marker for gastric cancer

Journal of Cellular and Molecular Medicine, Volume 24, Issue 12, Page 6750-6761, June 2020., 2020
Abstract Searching for the novel tumour biomarkers is pressing for gastric cancer diagnostication and prognostication. The serum specimens from patients diagnosed with locally advanced gastric carcinoma before operation and 4 week after surgery were collected, respectively, and serum proteome profiling was conducted by liquid chromatography–mass ...
Jiajia Shen, Jing Zhai, Xinqian Wu, Guiping Xie, Lizong Shen   +4 more
wiley   +1 more source

Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.

PLoS ONE, 2012
During embryonic development, hair cells and support cells in the sensory epithelia of the inner ear derive from progenitors that express Sox2, a member of the SoxB1 family of transcription factors.
Stephen D Freeman, Nicolas Daudet
doaj   +1 more source

Role of Cancer Stem Cell, Apoptotic Factor, DNA Repair, and Telomerase Toward Radiation Therapy Response in Stage IIIB Cervical Cancer

Oman Medical Journal, 2019
Objectives: Cancer stem cells are involved in radioresistant cancers. Transcription factors Sry-related HMG box (SOX2) and octamer binding transcription factor 4 (OCT4) can confer pluripotent cell characteristics and self-renewal ability and are involved
Lisnawati Rachmadi, Nurjati Chairani Siregar, Mpu Kanoko, Andrijono Andrijono, Saptawati Bardosono, Dwi Anita Suryandari, Sri Mutya Sekarutami, Bethy Suryawathy Hernowo   +7 more
doaj   +1 more source

Expanded expression of pro-neurogenic factor SoxB1 during larval development of gastropod Lymnaea stagnalis suggests preadaptation to prolonged neurogenesis in Mollusca. [PDF]

Front Neurosci
IntroductionThe remarkable diversity observed in the structure and development of the molluscan nervous system raises intriguing questions regarding the molecular mechanisms underlying neurogenesis in Mollusca. The expression of SoxB family transcription
Kurtova AI, Finoshin AD, Aparina MS, Gazizova GR, Kozlova OS, Voronova SN, Shagimardanova EI, Ivashkin EG, Voronezhskaya EE.   +8 more
europepmc   +2 more sources

Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

PLoS Biology, 2005
Little is known about the molecular mechanisms and intrinsic factors that are responsible for the emergence of neuronal subtype identity. Several transcription factors that are expressed mainly in precursors of the ventral telencephalon have been shown ...
Antigoni Ekonomou, Ilias Kazanis, Stavros Malas, Heather Wood, Pavlos Alifragis, Myrto Denaxa, Domna Karagogeos, Andrew Constanti, Robin Lovell-Badge, Vasso Episkopou   +9 more
doaj   +1 more source

Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy

Stem Cells International, Volume 2018, Issue 1, 2018., 2018
Over many decades, constructing genetically and phenotypically stable lines of neural stem cells (NSC) for clinical purposes with the aim of restoring irreversibly lost functions of nervous tissue has been one of the major goals for multiple research groups. The unique ability of stem cells to maintain their own pluripotent state even in the adult body
E. M. Samoilova, V. A. Kalsin, N. M. Kushnir, D. A. Chistyakov, A. V. Troitskiy, V. P. Baklaushev, Hee-Woo Lee   +6 more
wiley   +1 more source

The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns

Neural Plasticity, Volume 2018, Issue 1, 2018., 2018
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles during the inner ear development.
Shaofeng Liu, Yunfeng Wang, Yongtian Lu, Wen Li, Wenjing Liu, Jun Ma, Fuqin Sun, Mao Li, Zheng-Yi Chen, Kaiming Su, Wenyan Li, Clive R. Bramham   +11 more
wiley   +1 more source

The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration

WIREs Developmental Biology, Volume 5, Issue 4, Page 408-428, July/August 2016., 2016
Reverse genetics and next‐generation sequencing unlocked a new era in biology. It is now possible to identify an animal(s) with the unique biology most relevant to a particular question and rapidly generate tools to functionally dissect that biology. This review highlights the rise of one such novel model system, the starlet sea anemone Nematostella ...
Michael J. Layden, Fabian Rentzsch, Eric Röttinger   +2 more
wiley   +1 more source