Early nervous system development in the chaetognath Spadella cephaloptera exhibits conserved bilaterian patterning features [PDF]
Frontiers in Cell and Developmental BiologyNervous systems display extensive diversity in structure and organization, yet a broadly conserved set of signaling pathway components and transcription factors is consistently associated with early neurogenesis in many animal lineages.
June F. Ordoñez +6 more
doaj +2 more sources
The Charcot–Marie–Tooth Neuropathy (CMTX3) Complex Structural Variation Causes Differential SOX3 Spatiotemporal Expression [PDF]
Human Mutation, Volume 2026, Issue 1, 2026.Charcot–Marie–Tooth (CMT) neuropathy is a clinically and genetically heterogeneous group of diseases characterized by the length‐dependent axonal degeneration of peripheral nerves. We previously mapped a rare form of X‐linked CMT, CMTX3, to a 5.7‐Mb interval on chromosome Xq26.3‐q27.1 and excluded the coding region of all known genes in the linkage ...
Alexandra Boyling +9 more
wiley +2 more sources
Generation of Chimera-Competent Avian iPSCs Using Defined Transcription Factors [PDF]
CellsiPSC technology is well established in mammals but remains underdeveloped in non-mammalian species. A major barrier to generating avian iPSCs has been the lack of species-specific reprogramming factors and culture conditions capable of supporting self ...
Xinyi Tong +7 more
doaj +2 more sources
Transcriptome Analysis Suggested Striking Transition Around the End of Epiboly in the Gene Regulatory Network Downstream of the Oct4‐Type POU Gene in Zebrafish Embryos [PDF]
Development, Growth &Differentiation, Volume 67, Issue 5, Page 245-269, June 2025.Transcriptome analysis of pou5f3‐regulated genes in zebrafish embryos showed that competence to pou5f3 regulation changes significantly before and after the end of epiboly. The target genes encoded a diverse array of proteins, including transcriptional regulators and signaling molecules.
Masaaki Ikeda +6 more
wiley +2 more sources
An insight into planarian regeneration
Cell Proliferation, Volume 55, Issue 9, September 2022., 2022 Genetic and molecular mechanisms for regeneration control on various tissues in planarian. Abstract Background Planarian has attracted increasing attentions in the regeneration field for its usefulness as an important biological model organism attributing to its strong regeneration ability.
Xin‐Yang Ge +4 more
wiley +1 more source
In Silico Identification of SOX1 Post-Translational Modifications Highlights a Shared Protein Motif
Cells, 2020 The transcription factor SOX1 is a key regulator of neural stem cell development, acting to keep neural stem cells (NSCs) in an undifferentiated state. Postnatal expression of Sox1 is typically confined to the central nervous system (CNS), however, its ...
Azaz Ahmad +4 more
doaj +1 more source
Reviews in Aquaculture, Volume 13, Issue 4, Page 1986-2003, September 2021., 2021 Abstract The Sry‐related high mobility group box (Sox) genes family is a group of transcription factors playing crucial roles during reproduction and development. At least 50% amino acid sequences of Sox protein family are similarity to the sex‐determining region on the Y chromosome (Sry).
Yacheng Hu, Binzhong Wang, Hejun Du
wiley +1 more source
BioEssays, Volume 43, Issue 7, July 2021., 2021 Development and maintenance of organs requires context‐specific regulation of stem cell activities. We hypothesize that these are dependent upon reciprocal interactions between the cell‐cycle machinery and regulators of stem cell differentiation. To support this, we discuss the mechanistic links between these processes, as well as their parallel ...
Jonas Muhr, Daniel W. Hagey
wiley +1 more source
A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
eLife, 2022 Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their neural function evolved is unclear ...
Eleni Chrysostomou +12 more
doaj +1 more source
Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. [PDF]
PLoS ONE, 2014 SOX14 is a member of the SOXB2 subgroup of transcription factors implicated in neural development. Although the first SOX14 gene in vertebrates was cloned and characterized more than a decade ago and its expression profile during development was revealed
Jelena Popovic +5 more
doaj +1 more source