Results 31 to 40 of about 180,085 (282)

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

PLoS Biology, 2009
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional ...
Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield   +14 more
doaj   +1 more source

Structural Mechanism behind Distinct Efficiency of Oct4/Sox2 Proteins in Differentially Spaced DNA Complexes. [PDF]

PLoS ONE, 2016
The octamer-binding transcription factor 4 (Oct4) and sex-determining region Y (SRY)-box 2 (Sox2) proteins induce various transcriptional regulators to maintain cellular pluripotency.
Dhanusha Yesudhas, Muhammad Ayaz Anwar, Suresh Panneerselvam, Prasannavenkatesh Durai, Masaud Shah, Sangdun Choi   +5 more
doaj   +1 more source

Epigenetic modification mechanism of histone demethylase KDM1A in regulating cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury [PDF]

PeerJ, 2022
Hypoxia and reoxygenation (H/R) play a prevalent role in heart-related diseases. Histone demethylases are involved in myocardial injury. In this study, the mechanism of the lysine-specific histone demethylase 1A (KDM1A/LSD1) on cardiomyocyte apoptosis ...
Lin He, Yanbo Wang, Jin Luo
doaj   +2 more sources

Fast and non-invasive PCR sexing of primates: apes, Old World monkeys, New World monkeys and Strepsirrhines

BMC Ecology, 2006
Background One of the key tools for determining the social structure of wild and endangered primates is the ability to sex DNA from small amounts of non-invasive samples that are likely to include highly degraded DNA.
Fredsted Tina, Villesen Palle
doaj   +1 more source

Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
doaj   +1 more source

Associations between diet, physical activity and body fat distribution: a cross sectional study in an Indian population. [PDF]

, 2015
BACKGROUND: Obesity is a growing health problem in India and worldwide, due to changes in lifestyle. This study aimed to explore the independent associations between dietary and physical activity exposure variables and total body fat and distribution in ...
Ben-Shlomo, Yoav, Bowen, Liza, Ebrahim, Shah, Ekelund, Ulf, Kinra, Sanjay, Krishna, KV Radha, Kulkarni, Bharati, Kuper, Hannah, Sullivan, Ruth, Taylor, Amy E, Wells, Jonathan CK   +10 more
core   +4 more sources

miR-380-3p regulates melanogenesis by targeting SOX6 in melanocytes from alpacas (Vicugna pacos)

BMC Genomics, 2019
Background Melanocytes are derived from neural crest stem cells in the embryonic stage. In mature melanocytes, a series of complex enzyme-catalyzed reactions leads to the production of melanins, which determine the hair and skin colors of animals.
Xuexian Liu, Bin Du, Pengqian Zhang, Junzhen Zhang, Zhiwei Zhu, Bo Liu, Ruiwen Fan   +6 more
doaj   +1 more source

Roles of the Y chromosome genes in human cancers

Asian Journal of Andrology, 2015
Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromosome harbors male-specific genes ...
Tatsuo Kido, Yun-Fai Chris Lau
doaj   +1 more source

Molecular docking investigation of calotropone as a potential natural therapeutic agent against pancreatic cancer

Journal of Advanced Pharmaceutical Technology & Research, 2022
A natural bioactive compound named calotropone has been reported as a drug candidate for several cancers, including pancreatic cancers. Herein, we used molecular docking approach to test the possible mechanisms of action of calotropone in inhibiting the ...
Agnia Purnama, Diva Rayyan Rizki, Intan Qanita, Muhammad Iqhrammullah, Khairunnas Ahmad, Vivi Mardina, Kana Puspita, Kartini Hasballah   +7 more
doaj   +1 more source

A procedure to detect 6 basic STSs and 11 extended STSs in the AZF region using multiplex PCR

Vietnam Journal of Science, Technology and Engineering, 2022
Microdeletions of Y chromosomes frequently occur in 3 subregions of the AZF, namely, AZFa, AZFb, and AZFc, with 6 basic STS marker sequences, which are sY84, sY86 (AZFa), sY127, sY134 (AZFb), and sY254, sY255 (AZFc). According to EAA/EMNQ guidelines, 11
Thi Lan Anh Luong, Thu Lan Hoang, Minh Ngoc Nguyen, Ngoc Dung Nguyen   +3 more
doaj   +1 more source