Results 11 to 20 of about 49,304 (232)

Polymorphisms in the Promoter Region of the Chinese Bovine Gene [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2013
The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis.
M. J. Li   +6 more
doaj   +1 more source

SOX2 Regulates lncRNA CCAT1/MicroRNA-185-3p/FOXP3 Axis to Affect the Proliferation and Self-Renewal of Cervical Cancer Stem Cells

open access: yesNanoscale Research Letters, 2021
It has been presented the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We aim to discuss the effect of sex-determining region Y-box 2 (SOX2)/lncRNA colon cancer-associated transcript-1 (CCAT1)/microRNA-185-3p (miR-185-3p)/forkhead box ...
Li Zhang   +3 more
doaj   +1 more source

Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences [PDF]

open access: yesBiochemical Journal, 2003
The zinc metalloprotease thimet oligopeptidase (EP24.15) is found predominantly in the neuroendocrine–gonadal axis where it is implicated in the processing of bioactive peptides, including GnRH (gonadotropin-releasing hormone), β-neoendorphin, α-neoendorphin and dynorphin(1–8), the progression of spermatogenesis and the normal clearance of β-amyloid in
Morrison, Lesley S., Pierotti, Adrian R.
openaire   +2 more sources

Why women see differently from the way men see? A review of sex differences in cognition and sports

open access: yesJournal of Sport and Health Science, 2014
The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal development and last through entire lifespan.
Rena Li
doaj   +1 more source

Downregulation of long non‐coding RNA Opa interacting protein 5‐antisense RNA 1 inhibits breast cancer progression by targeting sex‐determining region Y‐box 2 by microRNA‐129‐5p upregulation [PDF]

open access: yesCancer Science, 2018
Several studies have shown an important role for long non‐coding RNA (lncRNA) in breast cancer progression. The present study investigated the role of lncRNA Opa interacting protein 5‐antisense RNA 1 (OIP5‐AS1) in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and in breast cancer cell lines, and OIP5 ...
Huijuan Zeng   +9 more
openaire   +2 more sources

X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells

open access: yesBiology of Sex Differences, 2018
Background Sexual dimorphism in DNA methylation levels is a recurrent epigenetic feature in different human cell types and has been implicated in predisposition to disease, such as psychiatric and autoimmune disorders. To elucidate the genetic origins of
Bianca Ho   +15 more
doaj   +1 more source

Abnormal Sex Chromosome Constitution and Longitudinal Growth: Serum Levels of Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein-3, Luteinizing Hormone, and Testosterone in 109 Males with 47,XXY, 47,XYY, or Sex-Determining Region of the Y Chromosome (SRY)-Positive 46,XX Karyotypes [PDF]

open access: yesThe Journal of Clinical Endocrinology & Metabolism, 2008
Abstract Context: Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles. Aim: The aim of the study was to evaluate the role of abnormal chromosome constitution for longitudinal growth in ...
Aksglaede, Lise   +2 more
openaire   +3 more sources

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

open access: yesPLoS Biology, 2009
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional ...
Debora Bogani   +14 more
doaj   +1 more source

A chromosome-level genome assembly of Hong Kong catfish (Clarias fuscus) uncovers a sex-determining region

open access: yesBMC Genomics, 2023
Background Hong Kong catfish (Clarias fuscus) is an ecologically and economically important species that is widely distributed in freshwater regions of southern China. Hong Kong catfish has significant sexual growth dimorphism. The genome assembly of the
Chang-Xu Tian   +11 more
doaj   +1 more source

High expression of microRNA-208 is associated with cardiac hypertrophy via the negative regulation of the sex-determining region Y-box 6 protein

open access: yesExperimental and Therapeutic Medicine, 2015
The aim of this study was to investigate the expression levels of microRNA-208 (miR-208) and sex-determining region Y-box 6 (SOX6) in patients with progressive cardiac hypertrophy. A total of 50 patients with essential hypertension accompanied by left ventricular hypertrophy, and 30 healthy individuals were enrolled.
Xintao, Huang   +4 more
openaire   +3 more sources

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