Results 1 to 10 of about 180,085 (282)
Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. [PDF]
Diabetes, 2000 The SOX (sex-determining region [SRY]-type high mobility group [HMG] box) family of transcription factors play key roles in determining cell fate during organ development. In this study, we have identified a new human SOX gene, SOX13, as encoding the type 1 diabetes autoantigen, islet cell antigen 12 (ICA12). Sequence analysis showed that SOX13 belongs
H, Kasimiotis +8 more
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Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1 [PDF]
Journal of Experimental & Clinical Cancer Research, 2017 The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).The expression levels of SOX3 in OS tissues and OS cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and ...
Qiu, Manle +5 more
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Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences [PDF]
Biochemical Journal, 2003 The zinc metalloprotease thimet oligopeptidase (EP24.15) is found predominantly in the neuroendocrine–gonadal axis where it is implicated in the processing of bioactive peptides, including GnRH (gonadotropin-releasing hormone), β-neoendorphin, α-neoendorphin and dynorphin(1–8), the progression of spermatogenesis and the normal clearance of β-amyloid in
Morrison, Lesley S., Pierotti, Adrian R.
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Expression of sex-determining region Y-box protein 2 in breast cancer and its clinical significance
Saudi Medical Journal, 2017 Sex-determining region Y-box protein 2 (SOX2) is an embryo transcription factor located on chromosome 3q26.3-q27. It plays an important role in the maintenance of differentiation and self-renewal of pluripotent stem cells. Studies have shown that SOX2 is associated with multiple cancers and is overexpressed in many different phenotypes of breast cancer.
Feng, Xuesong, Lu, Mingqian
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Downregulation of long non‐coding
Cancer Science, 2018 Several studies have shown an important role for long non‐coding RNA (lncRNA) in breast cancer progression. The present study investigated the role of lncRNA Opa interacting protein 5‐antisense RNA 1 (OIP5‐AS1) in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and in breast cancer cell lines, and OIP5 ...
Huijuan Zeng +9 more
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Egyptian Journal of Pathology, 2022 Background Malignant mesothelioma can be difficult to be distinguished from lung adenocarcinoma without immunohistochemistry. However, conventional mesothelial markers until now do not have optimal sensitivity and specificity, necessitating the identification of new markers.
Marwa S. Abd Allah +2 more
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The Veterinary Journal, 2015 Pituitary-dependent hypercortisolism is a common endocrinopathy in dogs, caused by an adrenocorticotrophic hormone secreting pituitary tumour of the anterior or intermediate lobe. The prognosis of intermediate lobe adenomas is worse than that of anterior lobe adenomas, indicating the possible usefulness of melanotropic markers as prognosticators ...
van Rijn, Sarah J +9 more
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Experimental and Therapeutic Medicine, 2015 The aim of this study was to investigate the expression levels of microRNA-208 (miR-208) and sex-determining region Y-box 6 (SOX6) in patients with progressive cardiac hypertrophy. A total of 50 patients with essential hypertension accompanied by left ventricular hypertrophy, and 30 healthy individuals were enrolled.
Xintao, Huang +4 more
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Reports of biochemistry & molecular biology, 2016 The SRY gene (SRY) provides instructions for making a transcription factor called the sex-determining region Y protein. The sex-determining region Y protein causes a fetus to develop as a male. In this study, SRY of 15 spices included of human, chimpanzee, dog, pig, rat, cattle, buffalo, goat, sheep, horse, zebra, frog, urial, dolphin and killer whale ...
Masoume, Vakili Azghandi +4 more
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Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014 Pluripotent stem cells maintain their pluripotency and undifferentiated status through a network of transcription factors. Liver receptor homolog-1 (Lrh-1) is one of these, and regulates the expression of other important transcription factors such as Oct-3/4 and Nanog.
Masafumi Kanno +9 more
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