Results 1 to 10 of about 49,205 (133)

Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas

Veterinary Journal, 2015
Pituitary-dependent hypercortisolism is a common endocrinopathy in dogs, caused by an adrenocorticotrophic hormone secreting pituitary tumour of the anterior or intermediate lobe. The prognosis of intermediate lobe adenomas is worse than that of anterior lobe adenomas, indicating the possible usefulness of melanotropic markers as prognosticators ...
Jacques Drouin, Marianne Pouwer, Björn Meij   +2 more
exaly   +5 more sources

Sex determining region Y box protein 2 (SOX2) expression, alteration, regulation and its diagnostics, prognostics and therapeutics in lung cancer

Discover Oncology
Lung cancer is the leading cause of cancer death in China and worldwide. Sex determining region Y box protein 2 (SOX2) is involved in pluripotency regulation in embryonic stem cells, morphogenesis, and homeostasis of tracheobronchial epithelia, as well ...
Xia Jiang, Meiling Zheng, Lianmei Zhang, Dongmei Xu, Jingliang Cheng, Haoyue Deng, Chunli Wei, Junping Xian, Fangshuo Xu, Mazaher Maghsoudloo, Dabing Li, Wenzhe Ma, Junjiang Fu   +12 more
doaj   +2 more sources

Expression of sex-determining region Y-box protein 2 in breast cancer and its clinical significance

Journal of King Abdulaziz University, Islamic Economics, 2017
Sex-determining region Y-box protein 2 (SOX2) is an embryo transcription factor located on chromosome 3q26.3-q27. It plays an important role in the maintenance of differentiation and self-renewal of pluripotent stem cells. Studies have shown that SOX2 is associated with multiple cancers and is overexpressed in many different phenotypes of breast cancer.
Mingqian Lu
exaly   +3 more sources

Clinical applications of serum tissue inhibitor of matrix metalloproteinase 3 and sex determining region Y box protein 2 for an early diagnosis of renal injury in type 2 diabetes mellitus

Linchuang shenzangbing zazhi
Objective To explore the roles of serum tissue inhibitor of matrix metalloproteinase 3（TIMP3） and sex determining region Y box protein 2（SOX2） in an early diagnosis of renal injury in type 2 diabetes mellitus（T2DM）. Methods From April 2022 to April 2023，
Hong-li Zhang, Hai-cheng Wang, Hua Li, Rui-chao Wei, Ling Zeng   +4 more
doaj   +2 more sources

An Infertile Azoospermic Male With 45, X T(Yp;15) Karyotype

Journal of Family and Reproductive Health, 2021
Objective: 45, X is a very rare condition that usually results from Y/autosomal translocations or insertions. Here we present an infertile azoospermic man who had 45, X t(Yp;15) karyotype and deletion of AZF (azoospermia factor) gene region. Case report:
Maryam Abiri, Maryam Hassanlou, Nima Narimani, Marzieh Zamani, Zahra Moeini   +4 more
doaj   +1 more source

Determination of Sperm Sex Ratio in Bovine Semen Using Multiplex Real-time Polymerase Chain Reaction [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Gender selection is important in livestock industries; for example, female calves are required in the dairy industry. Sex-sorted semen is commonly used for the production of calves of the desired gender. However, assessment of the sex ratio of the sorted
Trisadee Khamlor, Petai Pongpiachan, Siwat Sangsritavong, Nipa Chokesajjawatee   +3 more
doaj   +1 more source

A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus. [PDF]

PLoS Genetics, 2015
Variation in the TGF-β signaling pathway is emerging as an important mechanism by which gonadal sex determination is controlled in teleosts. Here we show that amhy, a Y-specific duplicate of the anti-Müllerian hormone (amh) gene, induces male sex ...
Minghui Li, Yunlv Sun, Jiue Zhao, Hongjuan Shi, Sheng Zeng, Kai Ye, Dongneng Jiang, Linyan Zhou, Lina Sun, Wenjing Tao, Yoshitaka Nagahama, Thomas D Kocher, Deshou Wang   +12 more
doaj   +1 more source

Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. [PDF]

Diabetes, 2000
The SOX (sex-determining region [SRY]-type high mobility group [HMG] box) family of transcription factors play key roles in determining cell fate during organ development. In this study, we have identified a new human SOX gene, SOX13, as encoding the type 1 diabetes autoantigen, islet cell antigen 12 (ICA12). Sequence analysis showed that SOX13 belongs
H, Kasimiotis, M A, Myers, A, Argentaro, S, Mertin, S, Fida, T, Ferraro, J, Olsson, M J, Rowley, V R, Harley   +8 more
openaire   +2 more sources

Phenotype expansion of variants affecting p38 MAPK signaling in hypospadias patients

Orphanet Journal of Rare Diseases, 2022
Background Hypospadias is a congenital anomaly of the male urogenital system. Genetics factors play an important role in its pathogenesis. To search for potential causal genes/variants for hypospadias, we performed exome sequencing in a pedigree with ...
Defu Lin, Huakang Du, Sen Zhao, Bowen Liu, Hongcheng Song, Guannan Wang, Weiping Zhang, Haiyan Liang, Pei Liu, Chao Liu, Wenwen Han, Zhenwu Li, Yang Yang, Shuofan Chen, Lina Zhao, Xiaoxin Li, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Ning Sun, Nan Wu   +19 more
doaj   +1 more source

Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1 [PDF]

Journal of Experimental & Clinical Cancer Research, 2017
The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).The expression levels of SOX3 in OS tissues and OS cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and ...
Qiu, Manle, Chen, Daoyun, Shen, Chaoyong, Shen, Ji, Zhao, Huakun, He, Yaohua   +5 more
openaire   +2 more sources