Results 51 to 60 of about 4,114,102 (347)

Dealing With Uncertainty and Lack of Knowledge in Diverse Sex Development: Controversies on Early Surgery and Questions of Consent

Sexual Medicine, 2020
Introduction: Diverse sex development (dsd) is an umbrella term for different congenital conditions with incongruence of chromosomal, gonadal, and phenotypic sex characteristics.
Ute Lampalzer, PhD, Peer Briken, MD, Katinka Schweizer, PhD   +2 more
doaj   +1 more source

Sex differences in the human metabolome

Biology of Sex Differences, 2022
Background The sexual dimorphism represents one of the triggers of the metabolic disparities between the organisms, advising about wild implications in research or diagnostics contexts.
M. Costanzo, M. Caterino, G. Sotgiu, M. Ruoppolo, F. Franconi, I. Campesi   +5 more
semanticscholar   +1 more source

Sex, sexes, sex roles, and gender in land plants

American Journal of Botany, 2023
"When we view gender as an accomplishment, an achieved property of situated conduct, our attention shifts from matters internal to the individual and focuses on interactional and, ultimately, institutional arenas. In one sense, of course, it is individuals who 'do' gender.
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

How psychopathy is associated with the level and change of impulsivity in correctional treatment

European Psychiatry
Introduction Research indicates that psychopathy can hinder treatment success and can lead to dropout. Impulsivity is a complex construct that overlaps with psychopathic personality traits and is often targeted in forensic psychotherapy due to its ...
A. Voulgaris, P. Briken, E. Stück
doaj   +1 more source

ATR is a multifunctional regulator of male mouse meiosis

Nature Communications, 2018
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner   +15 more
doaj   +1 more source

More than a virus: a qualitative study of the social implications of hepatitis B infection in China

International Journal for Equity in Health, 2017
Background China has the largest absolute number of people living with hepatitis B with up to 300,000 people estimated to die each year from hepatitis B related diseases.
J. Wallace, M. Pitts, C. Liu, V. Lin, B. Hajarizadeh, J. Richmond, S. Locarnini   +6 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The interplay of aggression and psychopathy in a correctional treatment setting

European Psychiatry
Introduction Aggression is a relevant risk factor for criminal behavior. Psychopathy is known to correlate with a higher risk for violent offenses and research suggests that successful therapy of psychopathy is complicated.
A. Voulgaris, P. Briken, E. Stück
doaj   +1 more source

Access to infertility investigations and treatment for HIV+ people: a survey of Australian infertility clinics

Australian and New Zealand Journal of Public Health, 2004
Objective:To examine the availability in Australia of investigations and treatment of infertility for people infected with HIV. Methods:The study was a questionnaire survey of all identified Australian IVF clinics undertaken in 2002.
Marian Pitts, Penelope Shields
doaj   +1 more source