Results 101 to 110 of about 4,675,098 (246)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Comparative genomics illuminates karyotype and sex chromosome evolution of sharks

Cell Genomics
Summary: Chondrichthyes is an important lineage to reconstruct the evolutionary history of vertebrates. Here, we analyzed genome synteny for six chondrichthyan chromosome-level genomes.
Jiahong Wu, Fujiang Liu, Jie Jiao, Haoran Luo, Shiyu Fan, Jiao Liu, Hongxiang Wang, Ning Cui, Ning Zhao, Qingming Qu, Shigehiro Kuraku, Zhen Huang, Luohao Xu   +12 more
doaj   +1 more source

Investigation into turtle sex chromosome and genome evolution [PDF]

This dissertation explores the complex evolutionary dynamics of sex chromosomes and genome evolution in turtles. Turtles are an ideal model for studying sex chromosome evolution due to their diverse sex determination mechanisms, including both ...
Bista, Basanta
core   +1 more source

General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq [PDF]

, 2011
Background Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to ...
Bryk, Jaroslaw,, Bryk, Jarek, Wolf, Jochen B. W.,, Wolf, Jochen BW, Bryk Jarosław, Jochen BW Wolf, Bryk, J., Wolf, J., Jarosław Bryk, Wolf Jochen BW   +9 more
core   +2 more sources

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

X chromosome inactivation during Drosophila spermatogenesis [PDF]

, 2007
Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have “escaped” the X chromosome and moved to ...
Baines, J., Hense, Winfried, Parsch, John, John Parsch, Baines, John F., Parsch John, Hense Winfried, Baines John F, Hense, W., John F Baines, Winfried Hense, Parsch, J.   +11 more
core   +2 more sources

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

Evolution of gene dosage on the Z-chromosome of schistosome parasites

eLife, 2018
XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear.
Marion A L Picard, Celine Cosseau, Sabrina Ferré, Thomas Quack, Christoph G Grevelding, Yohann Couté, Beatriz Vicoso   +6 more
doaj   +1 more source

reveals early events of sex chromosome evolution

, 2005
The dioecious plant species Silene latifolia has a sex determination mechanism based on an active Y chromosome. Here, we used inter-specific hybrids in the genus Silene to study the effects of gene complexes on the Y chromosome.
Ioan Negrutiu, Vyskot, B., Negrutiu, I., Markova, M., Hobza, R., Deborah Charlesworth, Michaela Markova, Zluvova, J., Michael Nicolas, Jitka Zluvova, Martina Lengerova, Bohuslav Janousek, Janousek, B., Boris Vyskot, Nicolas, M., Charlesworth, D., Roman Hobza, Lengerova, M.   +17 more
core   +1 more source