Results 31 to 40 of about 86,282 (258)
Genomic evidence reveals three W-autosome fusions in Heliconius butterflies.
PLoS GeneticsSex chromosomes are evolutionarily labile in many animals and sometimes fuse with autosomes, creating so-called neo-sex chromosomes. Fusions between sex chromosomes and autosomes have been proposed to reduce sexual conflict and to promote adaptation and ...
Nicol Rueda-M +11 more
doaj +1 more source
BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis
Biology Open, 2015 Meiosis is precisely regulated by the factors involved in DNA damage response in somatic cells. Among them, phosphorylation of H2AX on Serine 139 (γH2AX) is an essential signal for the silencing of unsynapsed sex chromosomes during male meiosis. However,
Tyler J. Broering +5 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Ecology and EvolutionAn advantage of sex chromosomes may be the potential to reduce sexual conflict because they provide a basis for selection to operate separately on females and males.
Anika Minovic, Masafumi Nozawa
doaj +1 more source
Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki +8 more
wiley +1 more source
Kinetic activity of the sex chromosomes of Mormidea paupercula (Heteroptera: Pentatomidae)
European Journal of Entomology, 2010 In Mormidea paupercula (n = 6 + XY in males), the presence of a CMA3-bright band in the telomeric regions on both sex chromosomes allowed the analysis of the kinetic activity of the sex univalents and XY pseudobivalent at the first and second meiotic ...
Pablo Javier REBAGLIATI +1 more
doaj +1 more source
Ever-young sex chromosomes in European tree frogs.
PLoS Biology, 2011 Non-recombining sex chromosomes are expected to undergo evolutionary decay, ending up genetically degenerated, as has happened in birds and mammals. Why are then sex chromosomes so often homomorphic in cold-blooded vertebrates?
Matthias Stöck +13 more
doaj +1 more source
Nature Communications, 2021 During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex ...
Yisrael Rappaport +5 more
doaj +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Natural triploidy in Leporinus cf. elongatus bearing sex chromosomes
Genetics and Molecular Biology, 2007 Although several cases of natural triploidy in fish have already been described, spontaneous polyploidy in species with differentiated sex chromosomes are rare. We report the occurrence of a triploid fish (3n = 81) Leporinus cf.
Wagner Franco Molina +2 more
doaj +1 more source