Results 1 to 10 of about 3,546,027 (344)

A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta

Biology of Sex Differences, 2021
Background Human placental DNA methylation (DNAme) data is a valuable resource for studying sex differences during gestation, as DNAme profiles after delivery reflect the cumulative effects of gene expression patterns and exposures across gestation. Here,
Amy M. Inkster, Victor Yuan, Chaini Konwar, Allison M. Matthews, Carolyn J. Brown, Wendy P. Robinson   +5 more
doaj   +1 more source

Sex differences in number of X chromosomes and X-chromosome inactivation in females promote greater variability in hearing among males

Biology of Sex Differences, 2022
Highlights Greater variability in hearing thresholds across males than females for human listeners with thresholds within the normal range. Higher within-ear and between-ear correlations between thresholds for males than females consistent with sex ...
Van Summers
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Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis

Biology of Sex Differences, 2019
Background Postoperative cognitive dysfunction (POCD) is a common postoperative complication experienced by patients aged 65 years and older, and these older adults comprise more than one third of the surgical patients in the USA.
Katie J. Schenning, Charles F. Murchison, Nora C. Mattek, Jeffrey A. Kaye, Joseph F. Quinn   +4 more
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Smad4 and FoxH1 potentially interact to regulate cyp19a1a promoter in the ovary of ricefield eel (Monopterus albus)

Biology of Sex Differences
Background Cyp19a1a is a key enzyme in the pathway that converts androgens into estrogen and is regulated by TGF-β signaling. Smad4 and FoxH1 are downstream effectors of TGF-β signaling and may play important roles in ovarian development in M.
Qiqi Chen, Deying Yang, Mingqiang Chen, Jinxin Xiong, Junjie Huang, Wenxiang Ding, Kuo Gao, Bolin Lai, Li Zheng, Ziting Tang, Mingwang Zhang, Taiming Yan, Zhi He   +12 more
doaj   +1 more source

The role of the gut microbiome in sex differences in arterial pressure

Biology of Sex Differences, 2019
There has been intense interest in the role of the gut microbiome in human health and a broad range of diseases in recent years. In the context of cardiovascular disease, gut dysbiosis (defined as a change in the gut microbiome and the gut-epithelial ...
Anna L. Beale, David M. Kaye, Francine Z. Marques   +2 more
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The impact of sex and gender on immunotherapy outcomes

Biology of Sex Differences, 2020
Immunotherapies are often used for the treatment, remission, and possible cure of autoimmune diseases, infectious diseases, and cancers. Empirical evidence illustrates that females and males differ in outcomes following the use of biologics for the ...
Sabra L. Klein, Rosemary Morgan
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RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance

Biology of Sex Differences, 2022
Highlights Female RAGE−/− mice showed significantly improved glucose and insulin tolerance compared to male RAGE−/− mice. Female RAGE deficiency promotes M2 macrophage polarization in adipose tissues.
Zuoqin Du, Jiaqi Wu, Ziqian Feng, Xiaoyu Ma, Tao Zhang, Xin Shu, Jin Xu, Liqun Wang, Mao Luo, Jianbo Wu   +9 more
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Androgens and the developing hippocampus

Biology of Sex Differences, 2020
The hippocampus is central to spatial learning and stress responsiveness, both of which differ in form and function in males versus females, yet precisely how the hippocampus contributes to these sex differences is largely unknown.
Katherine E. Kight, Margaret M. McCarthy
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The role of visual experience in haptic spatial perception: evidence from early blind, late blind, and sighted individuals

Biology of Sex Differences
There is contradictory evidence on the effect that visual experience has on haptic abilities. Indeed, some studies have documented that a lack of vision (blindness) results in decreased haptic perception, whereas other studies report an enhanced haptic ...
Lara A. Coelho, Daniela E. Aguilar Ramirez, Serena Basta, Marta Guarischi, Claudia L. R. Gonzalez, Monica Gori   +5 more
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Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood

Biology of Sex Differences
Background Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions currently diagnosed through behavioral assessments in childhood, though neuropathological changes begin in utero.
Julia S. Mouat, Nickilou Y. Krigbaum, Sophia Hakam, Emily Thrall, George E. Kuodza, Julia Mellis, Dag H. Yasui, Piera M. Cirillo, Yunin J. Ludena, Rebecca J. Schmidt, Michele A. La Merrill, Irva Hertz-Picciotto, Barbara A. Cohn, Janine M. LaSalle   +13 more
doaj   +1 more source