Results 1 to 10 of about 1,670,842 (249)

Case Report: Prenatal Genetic Counseling to Parents of Fetuses Suspected of Having Ambiguous Genitalia

Frontiers in Pediatrics, 2021
The occurrence of fetuses suspected of having ambiguous genitalia will likely increase in the future. Currently, the impact of prenatal genetic counseling on parents' understanding and psychological preparedness has not been addressed.
Takeshi Sato, Takeshi Sato, Tomohiro Ishii, Tomohiro Ishii, Yu Yamaguchi, Yosuke Ichihashi, Yosuke Ichihashi, Daigo Ochiai, Hiroshi Asanuma, Hiroshi Asanuma, Tatsuo Kuroda, Tatsuo Kuroda, Tomonobu Hasegawa, Tomonobu Hasegawa   +13 more
doaj   +1 more source

396 Brain pathophysiology in SARS-CoV-2 disease

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2), which underlies the current COVID-19 pandemic, among other tissues, also targets the central nervous system (CNS).
Branka Milicic Stanic, Aline M.A. de Souza, Hong Ji, Xie Wu, Robert C. Speth, Nisha K. Duggal, Carolyn A. Ecelbarger, Juan M. Saavedra, Dexter L. Lee, Kathryn Sandberg   +9 more
doaj   +1 more source

Optimization of respiratory-gated auricular vagus afferent nerve stimulation for the modulation of blood pressure in hypertension

Frontiers in Neuroscience, 2022
BackgroundThe objective of this pilot study was to identify frequency-dependent effects of respiratory-gated auricular vagus afferent nerve stimulation (RAVANS) on the regulation of blood pressure and heart rate variability in hypertensive subjects and ...
Ronald G. Garcia, Ronald G. Garcia, Ronald G. Garcia, Rachel Staley, Rachel Staley, Sarah Aroner, Sarah Aroner, Jessica Stowell, Jessica Stowell, Roberta Sclocco, Roberta Sclocco, Roberta Sclocco, Vitaly Napadow, Vitaly Napadow, Vitaly Napadow, Riccardo Barbieri, Riccardo Barbieri, Riccardo Barbieri, Jill M. Goldstein, Jill M. Goldstein, Jill M. Goldstein, Jill M. Goldstein   +21 more
doaj   +1 more source

46 XY undervirulized male DSD: Reporting a patient with prenatally diagnosed disorder/difference of sex development (DSD) with heterozygous LHCGR mutations

Urology Case Reports, 2022
Leydig cell hypoplasia is a rare autosomal recessive condition caused by mutations in luteinizing hormone/chorionic gonadotropin receptor (LHCGR) genes in which 46, XY patients demonstrate a wide spectrum of disorders/differences of sex development (DSD)
Kiarad Fendereski, John Carey, Kathleen Timme, Katherine Hayes, Jessica Robnett, Anthony Schaeffer   +5 more
doaj   +1 more source

Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice

Frontiers in Neuroscience, 2023
IntroductionMaternal adversity during pregnancy influences neurodevelopment in human and model animal offspring. Adversity can result from stressors coming from many different directions ranging from environmental to nutritional and physiological to ...
Julietta A. Sheng, Robert J. Handa, Stuart A. Tobet, Stuart A. Tobet, Stuart A. Tobet, Stuart A. Tobet   +5 more
doaj   +1 more source

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

Biology of Sex Differences, 2023
Background Mammalian gonadal sex is determined by the presence or absence of a Y chromosome and the subsequent production of sex hormones contributes to secondary sexual differentiation.
Victorya Richardson, Nora Engel, Rob J. Kulathinal   +2 more
doaj   +1 more source

Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID

Biology of Sex Differences, 2023
Background Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to neuropathology, including neuroinflammation and white matter lesions that are a ...
Charly Abi-Ghanem, Abigail E. Salinero, David Kordit, Febronia M. Mansour, Richard D. Kelly, Harini Venkataganesh, Nyi-Rein Kyaw, Olivia J. Gannon, David Riccio, Gabrielle Fredman, Yannick Poitelon, Sophie Belin, Ashley M. Kopec, Lisa S. Robison, Kristen L. Zuloaga   +14 more
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X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

Biology of Sex Differences, 2023
Background and aim Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovascular health ...
Michele F. Buono, Ernest Diez Benavente, Mark Daniels, Barend M. Mol, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Sander W. van der Laan, Gerard Pasterkamp, Charlotte Onland-Moret, Michal Mokry, Hester M. den Ruijter   +11 more
doaj   +1 more source

Sex differences in type 2 diabetes: an opportunity for personalized medicine

Biology of Sex Differences, 2023
Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With new mandates to include sex as a biological variable in NIH-funded research, greater knowledge is forthcoming on how sex chromosomes ...
Meredith L. Johnson, Joshua D. Preston, Cetewayo S. Rashid, Kevin J. Pearson, J. Nina Ham   +4 more
doaj   +1 more source

Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell

Biology of Sex Differences, 2023
Background The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the NAc (NAcSh) have been implicated in driving the motivation to seek reward through ...
Caroline S. Johnson, Andrew D. Chapp, Erin B. Lind, Mark J. Thomas, Paul G. Mermelstein   +4 more
doaj   +1 more source