Results 101 to 110 of about 4,553,166 (361)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dispersal and population structure at different spatial scales in the subterranean rodent Ctenomys australis [PDF]

, 2010
This study was funded by grants from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP5838), Agencia de Promoción Científica y Tecnológica de la Argentina (PICTO1-423, BID-1728/OC-AR), and the programme ECOS-Sud France/Argentina ...
Gaggiotti, Oscar E., Kittlein, Marcelo J., Lessa, Enrique P., Mapelli, Fernando J., Mora, Matias S.   +4 more
core   +1 more source

Transcriptome Analysis of Flower Sex Differentiation in Jatropha curcas L. Using RNA Sequencing

PLoS ONE, 2016
Background Jatropha curcas is thought to be a promising biofuel material, but its yield is restricted by a low ratio of instaminate / staminate flowers (1/10-1/30).
Gang Xu, Jian Huang, Yong Yang, Yin-an Yao   +3 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Provenance does matter: links between winter trophic segregation and the migratory origins of European robins [PDF]

, 2016
Amongst migratory species, it is common to find individuals from different populations or geographical origins sharing staging or wintering areas.
Bearhop, Stuart,, Campos, Ana R.,, Catry, Paulo,, Granadeiro, José Pedro,, Lund University., Neto, Júlio M.,, Newton, Jason,, Ramos, Jaime,   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Male and female stem cells and sex reversal in Hydra polyps [PDF]

, 1986
Single interstitial stem cells of male polyps of Hydra magnipapillata give rise to clones that differentiate either male or female gametes. To test the sexual stability of these clones, stem cells were recloned.
Bosch, Thomas C. G., David, Charles N.
core  

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]

, 2012
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier, AM Talman, Andrew Tomlins, C Aurrecoechea, Christian Doerig, CJ Tonkin, EK De Silva, F Silvestrini, J Miao, JA Braks, KG Le Roch, L O’Regan, L Reininger, L Reininger, L Reininger, LM Quarmby, Luc Reininger, M Dyer, MC Bruce, Miguel Garcia, N Hall, P Alano, R Carter, RE Sinden, S Eksi, S Singh, SM Khan, Sylke Müller   +27 more
core   +6 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Identification, Expression and Evolutional Analysis of Two cyp19-like Genes in Amphioxus

Animals
The mechanism of sex determination and differentiation in animals remains a central focus of reproductive and developmental biology research, and the regulation of sex differentiation in amphioxus remains poorly understood.
Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu   +4 more
doaj   +1 more source