Results 81 to 90 of about 371,220 (313)

Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Pelodiscus sinensis)

Animals
The DKK family is a canonical small family of WNT antagonists. Though recent studies have suggested that the DKK gene family may be involved in sex differentiation in Pelodiscus sinensis, there are still a lot of things about the DKK gene family that we ...
Yongchang Wang, Junxian Zhu, Chen Chen, Liqin Ji, Xiaoyou Hong, Xiaoli Liu, Haigang Chen, Chengqing Wei, Junjie Zhang, Xinping Zhu, Wei Li   +10 more
doaj   +1 more source

[Sex differentiation and its anomalies] [PDF]

, 1996
Sex determination and differentiation is a sequential process that involves genetic, gonadal, phenotypic and psychological sex. Sex determination is primarily testis determination.
TATO', Luciano, ZAMBONI, Giorgio, ANTONIAZZI, Franco   +2 more
core  

Inbreeding and selection on sex ratio in the bark beetle Xylosandrus germanus [PDF]

, 2011
Background: Local Mate Competition (LMC) theory predicts a female should produce a more female-biased sex ratio if her sons compete with each other for mates.
Keller, Laurent, Christian Bernasconi, Keller, L., David M Shuker, Bernasconi, Christian, Katharina Peer, Peer Katharina, Bernasconi Christian, Shuker, D.M., Keller Laurent, Shuker David M, Peer, Katharina, Laurent Keller, Taborsky, M., Taborsky, Michael, Bernasconi, C., Shuker, David M., Peer, K., Taborsky Michael, Michael Taborsky   +19 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cloning and expression analysis of the glucocorticoid receptors and the effects of cortisol in sex differentiation in protogynous hermaphroditic swamp eel, Monopterus albus

Frontiers in Marine Science
Cortisol is the major glucocorticoid, which is considered to be a key factor linking the environmental stress and sex differentiation in teleosts. In the present study, we explored the possible role of cortisol in sex differentiation in a protogynous ...
Jialin Su, Lei Sun, Jiaqi Yang, Weizhi Yao, Hongyan Xu, Ke Feng   +5 more
doaj   +1 more source

Widespread sex differences in gene expression and splicing in the adult human brain. [PDF]

, 2013
There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field
Ramasamy, Adaikalavan, Ryten, Mina, Ramasamy, A, Smith, C, Ryten, M, Trabzuni, D, Walker, R, Smith, Colin, Smith, C; id_orcid, Trabzuni, Daniah, Imran, S, Weale, M, Hardy, John, ?, ?, Weale, Michael E, Hardy, J, North American Brain Expression Consortium, Weale, ME, Imran, Sabaena, Walker, Robert   +19 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Melav2, an elav-like gene, is essential for spermatid differentiation in the flatworm Macrostomum lignano [PDF]

, 2009
Background Failure of sperm differentiation is one of the major causes of male sterility. During spermiogenesis, spermatids undergo a complex metamorphosis, including chromatin condensation and cell elongation. Although the resulting sperm morphology and
Ladurner, P., Ladurner, Peter, De Mulder, K., Schärer, L., Scharer, Lukas, Sekii, K., Salvenmoser, Willi, Salvenmoser, W., Sekii, Kiyono, De Mulder, Katrien   +9 more
core   +1 more source