Results 61 to 70 of about 769,508 (312)

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]

, 2016
Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent, Davis, Anna Jane, Gao, Yang, Li, Qinglei, Sansom, Owen, Vincent, David   +5 more
core   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

eLife
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic fate in ...
Adriana K Alexander, Karina F Rodriguez, Yu-Ying Chen, Ciro Amato, Martin A Estermann, Barbara Nicol, Xin Xu, Humphrey HC Yao   +7 more
doaj   +1 more source

Sex-biased mouse liver lincRNAs: validation and impact of mouse knockout models that perturb hepatic growth signaling [PDF]

, 2016
Sexual dimorphism has a broad impact on human health and disease, including autoimmune diseases, cardiovascular diseases, and liver diseases, specifically hepatocellular carcinoma.
Yilmaz, Feyza
core   +1 more source

Sex assignment in conditions affecting sex development [PDF]

, 2017
The newborn infant with atypical genitalia presents a challenging clinical scenario and requires expert input. There have been appreciable advances in our knowledge of the underlying causes that may lead to a mere difference or a more serious disorder of
Ahmed, S. Faisal, Markosyan, Renata
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Comparative Transcriptomic Analysis of Male and Female Gonads in the Zig-Zag Eel (Mastacembelus armatus)

Fishes
The zig-zag eel (Mastacembelus armatus) is a unique economic fish species in China and exhibits significant dimorphism of male and female phenotypes. Cultivating all-male seedlings can significantly improve production efficiency.
Fangyu Cui, Yuanyuan Wang, Haiyan Liang, Yexin Yang, Zhiyong Jiang, Jiahuan Song, Chao Liu, Yuli Wu, Xidong Mu, Yi Liu   +9 more
doaj   +1 more source

Prenatal Diagnosis of mos45,X/46,X,+mar in a Fetus With Normal Male External Genitalia and a Literature Review

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: Prenatal diagnosis of mos45,X/46,X,+mar is difficult in genetic counseling. Patients with the presence of a Y-derived marker may manifest male or female external genitalia. Here, we report a fetus with phenotypically male external genitalia of
Shu-Chin Chien, Chih-Ping Chen, Chyi-Chyang Lin, Li-Chia Huang, Cheng-Tiao Hsieh, Fuu-Jen Tsai   +5 more
doaj   +1 more source

Effects of Different Chemicals on Sexual Regulation in Persimmon (Diospyros kaki Thunb.) Flowers

Frontiers in Plant Science, 2022
Research on crop sexuality is important for establishing systems for germplasm innovation and cultivating improved varieties. In this study, androecious persimmon trees were treated with various concentrations of ethrel (100, 500, and 1,000 mg/L) and ...
Liyuan Wang, Huawei Li, Yujing Suo, Weijuan Han, Songfeng Diao, Yini Mai, Yiru Wang, Jiaying Yuan, Lingshuai Ye, Tingting Pu, Qi Zhang, Peng Sun, Fangdong Li, Jianmin Fu   +13 more
doaj   +1 more source

Sex Differences in Recombination in Sticklebacks. [PDF]

, 2018
Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in Gasterosteus sticklebacks. Using whole-genome sequencing of 15 crosses between G. aculeatus and G.
Cheng, Changde, Dagilis, Andrius J, Ishikawa, Asano, Kirkpatrick, Mark, Kitano, Jun, Peichel, Catherine L, Sardell, Jason M   +6 more
core   +3 more sources