Results 251 to 260 of about 371,220 (313)

Dataset for selection of stable reference genes for accurate quantitative gene expression analysis in silvertip tetra (Hasemania nana): Implications for sex differentiation and determination. [PDF]

Data Brief
Lee HJ, Kim KT, Kim MS, Lee SY.
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
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Abnormalities of Sex Differentiation

Hormone Research, 2008
Sex differentiation is determined by a cascade of events proceeding from chromosomal sex to the completion of sexual maturation at puberty. Many factors involved in this cascade have been identified. Here we focus on DAX-1, androgen receptor and cytochrome P450cl7, and discuss their functions in sex differentiation.
H, Nawata, R, Takayanagi, T, Yanase, S, Ikuyama, T, Okabe   +4 more
openaire   +2 more sources

Sex Determination and Differentiation

New England Journal of Medicine, 2004
This review elucidates the molecular mechanisms of sex determination and sex differentiation with examples from embryology, animal models, and clinical syndromes. Sex reversal, defective masculinization, pseudohermaphroditism, and syndromes involving the gonads and other organs are some of the clinical problems discussed.
David T, MacLaughlin, Patricia K, Donahoe   +1 more
openaire   +2 more sources

Endocrine and environmental aspects of sex differentiation in fish [PDF]

Cellular and Molecular Life Sciences, 1999
This paper reviews the current knowledge concerning the endocrine and environmental regulations of both gonadal sex differentiation in gonochoristic and sex inversion in hermaphroditic fish. Within the central nervous system, gonadotropins seem to play a
Yann Guiguen, Alexis Fostier
exaly   +2 more sources

SEX DIFFERENTIATION IN AMPHIBIA

Nature, 1946
THE research which is summarized below was based on the well-known investigations of Witschi, who showed that at an early stage of development the amphibian gonad consists of a cortex and medulla. At a later stage, sex differentiation is marked by an increase of cortex relative to medulla or vice versa.
openaire   +2 more sources

Sex Differentiation in Mammals

Nature, 1967
Sex does not appear to be determined by the action of conventional genes. Heterochromatin—the substance of sex chromosomes—does, however, provide some clues as to how sexual differentiation may be brought about.
openaire   +2 more sources

Abnormal sex differentiation

The Journal of Pediatrics, 1984
Rappel des connaissances actuelles sur les mecanismes de la differenciation sexuelle normale et revue des progres recemment accomplis dans l'analyse et le diagnostic des anomalies de cette differenciation par troubles de la synthese ou du metabolisme de la testosterone ou de l'action des androgenes, anomalies de la differenciation gonadique, presence d'
openaire   +2 more sources

[Sex differentiation and sex chromosomes].

Nihon rinsho. Japanese journal of clinical medicine, 2004
The mechanisms for sex differentiation and the genes on the sex chromosomes are varied among different species. For human, SRY is the only testis-determining factor on the Y chromosome and triggers the cascade for male sex-determination. However, even if normal SRY exists, the haploinsufficienty of SOX9 or KTS+ splicing form of WT-1 can cause male-to ...
Toshikatsu, Shinka, Yutaka, Nakahori
openaire   +1 more source

Sex Differentials in the Earnings of Ph.D.s

Industrial and Labor Relations Review, 1978
Using a survey of two cohorts of men and women who received Ph.D.s in the years 1958-63 and 1967-72, the authors test two hypotheses: (1) that the relatively lower earnings of highly educated women can be explained largely by their career interruptions and by their lesser willingness to accumulate human capital in anticipation of such interruptions ...
M A, Ferber, B, Kordick
openaire   +2 more sources