Results 51 to 60 of about 2,126,536 (362)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Impact of a theoretically based sex education programme (SHARE) delivered by teachers on NHS registered conceptions and terminations: final results of cluster randomised trial [PDF]

open access: yes, 2006
<b>Objective</b>: To assess the impact of a theoretically based sex education programme (SHARE) delivered by teachers compared with conventional education in terms of conceptions and terminations registered by the NHS.
Abraham, C.   +6 more
core   +3 more sources

Popular education and hygiene propaganda: Paolo Mantegazza and the scientific pedagogy of his almanacs

open access: yesRicerche di Pedagogia e Didattica, 2019
The present paper aims at providing a portrait of Paolo Mantegazza as educator and hygienist. With the publication of his popular almanacs on hygiene, that started in 1866, and following the precepts of what we might call "scientific pedagogy ...
Matteo Loconsole
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

DEFENDING ALL-MALE EDUCATION: A NEW CULTURAL MOMENT FOR A RENEWED DEBATE [PDF]

open access: yes, 2001
Although all-female schools still prosper and are defended by members of the academic elite, an all-male college has become a near-extinct species. Many people are surprised such a creature still exists.
Webb, Stephen H.
core   +1 more source

Parents as agents of informal sex education: what to do?

open access: yesПсихология и Психотерапия Семьи, 2018
This article was born out of the numerous conversations of the author with parents over the past five years and discussions about educational articles. In the article, the reader is offered a short historical overview of the conditions in which a certain
Marina Travkova
doaj  

Quantifying disparities in air pollution exposures across the United States using home and work addresses [PDF]

open access: yesarXiv, 2023
While human mobility plays a crucial role in determining air pollution exposures and health risks, research to-date has assessed risks based solely on residential location. Here we leveraged a database of ~ 130 million workers in the US and published PM2.5 data between 2011-2018 to explore how incorporating information on both workplace and residential
arxiv  

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

open access: yesFEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa   +13 more
wiley   +1 more source

The Impact of Abstinence-Only Sex Education Programs in the United States on Adolescent Sexual Outcomes [PDF]

open access: yes, 2019
Though there are many evaluations of abstinence-only sex education programs in the United States, there is a relatively small body of literature exploring the programs’ impact specifically on adolescent sexual behavior.
Heels, Sonja W.
core   +2 more sources

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