Results 141 to 150 of about 95,845 (291)

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pang   +4 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

042 Vagal Activity During Physiological Sexual Arousal in Women With and Without Sexual Dysfunction

The Journal of Sexual Medicine, 2016
Cindy M. Meston, Carey S. Pulverman, Amelia M. Stanton   +2 more
openaire   +2 more sources

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Advanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian, Jinguo Zhu, Yanwei He, Haocheng Qin, Pingkang Qian, Bingfeng Sun, Haoqiang Huang, Chen Kuang, Quan Yang, Yuxi Ou, Rong Sun, Feng Xu, Xianwen Wang, Zhiwen Luo, Qing Wang   +14 more
wiley   +1 more source

Transplantation and Erectile Dysfunction [PDF]

, 1992
Djamilian, Mohamad H., Jonas, Udo, Stief, Christian Georg, Thon, Walter F., Truß, M.   +4 more
core   +1 more source

Gastric Distension Index: A Novel Radiographic Marker Associated With Postoperative Gastric Stasis After Gastrectomy

Annals of Gastroenterological Surgery, EarlyView.
This study introduces the Hiki Index (HI), a novel radiographic metric based on upright abdominal X‐rays, to objectively assess postoperative gastric dilatation after gastrectomy. The HI demonstrated strong predictive value for gastrointestinal symptoms and the need for therapeutic intervention, offering a practical tool for early detection and ...
Hiroki Harada, Yoshiko Yamaoka, Akiko Watanabe, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Keishi Yamashita, Naoki Hiki   +9 more
wiley   +1 more source

Cloud‐Based Control System with Sensing and Actuating Textile‐Based IoT Gloves for Telerehabilitation Applications

Advanced Intelligent Systems, EarlyView.
Using cloud computing technology, a telerehabilitation application allows patients to perform exercises remotely. Sensor data from a textile‐based IoT glove is processed in the cloud and transmitted as exercise commands to an actuating T‐IoT glove worn by patients.
Kadir Ozlem, Cagatay Gumus, Ayse Feyza Yilmaz, Asli Tuncay Atalay, Ozgur Atalay, Gökhan Ince   +5 more
wiley   +1 more source

Impact of Infertility and Medically Assisted Reproduction Treatments on Female Sexuality. [PDF]

JBRA Assist Reprod
Bannour B, Salem D, Bannour R, Saad OKB, Bannour I.   +4 more
europepmc   +1 more source