Results 41 to 50 of about 15,928 (255)

Moderating role of performance anxiety, sexual knowledge and sexual attitude on the relationship between severity of sexual dysfunctions and marital problems

مجله علوم روانشناختی, 2016
Marital relationships are influenced by sexual dysfunctions resulting in development and or continuing marital problems. The present study aimed at examining the moderating role of performance anxiety, sexual knowledge and attitudes on the relationship ...
MohammadAli Besharat, Negar Mazloomhoseini, Masoud Gholamali Lavasani, BahramAli Ghanbari Hashemabadi   +3 more
doaj  

Sexual dysfunctions and sexual behaviors of normal weight, overweight and obese sexual minority men

European Psychiatry, 2021
Introduction With the growing recognition of overweightness and obesity as significant, international public health concerns, the body of research investigating the relationship between body mass index (BMI), sexual health and sexual functioning in ...
H. Pereira
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Breaking the Taboo: Unveiling the Prevalence and Predictors of Female Sexual Dysfunction in Tunisia

European Psychiatry
Introduction Female sexuality is a complex and multifactorial domain that can be influenced by a variety of psychological, biological, relational, and sociocultural factors.
K. Razki, A. Larnaout, C. Najar, S. Ben Aissa, R. Lansari, W. Melki   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sexuality of women aged 60+ with hypertension

Journal of Education, Health and Sport
Introduction Sexuality of people aged 60+ is a sphere that presents many challenges. Special attention should be paid to media messages that mainly glorify 'young and beautiful' individuals. There is little focus on the sexuality of seniors, alongside a
Agnieszka Pawełko, Maria Ciechacka, Ewelina Bąk   +2 more
doaj   +1 more source

Female Sexual Dysfunctions and Urogynecological Disorders [PDF]

European Medical Journal Urology, 2013
Female sexual dysfunctions are a highly prevalent and often-underestimated health problem and include disorders of sexual desire, arousal, orgasm and sexual pain, associated with self-distress. Pathophysiology of female sexual dysfunctions is complex and
Emillio Sacco, Daniele Tienforti
doaj  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Predictors for Low Frequencies of Patient-Physician Conversations Concerning Sexual Health at an Austrian University Hospital

Sexual Medicine, 2020
Introduction: Studies concerning barriers to patient-physician conversations about sexual health or, specifically, sexual functioning fail to go beyond descriptive analyses of such barriers. Aim: To identify barriers that predict the frequency of patient-
Nikola Komlenac, PhD, Margarethe Hochleitner, MD   +1 more
doaj   +1 more source