HPDL Variant Type Correlates With Clinical Disease Onset and Severity
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee +19 more
wiley +1 more source
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications [PDF]
, 2017 The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
Ahmed, S. Faisal +4 more
core +1 more source
Impotence and Sterility with Aberrations of the Sexual Function and Sex Gland Implantation. [PDF]
, 1918 G Frank Lydston
openalex +1 more source
KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini +24 more
wiley +1 more source
Sexual Function and Sexual Behavior in Women with Breast Cancer Having Sexual Distress, Zanjan, Iran [PDF]
Preventive Care in Nursing and Midwifery Journal, 2017 Background: Sexual relationships of women with breast cancer are affected by diagnostic and therapeutic procedures. Objectives: The aim of this study was to assess sexual function and sexual behavior in women with breast cancer having sexual distress in
Esmkhani M +4 more
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The Effects of Penicillin Administration on Menstrual and other Sexual Cycle Functions [PDF]
, 1947 A. McLachlan, D.D. Brown
openalex +1 more source
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
Sexual Function and Pessary Management among Women Using a Pessary for Pelvic Floor Disorders.
Journal of Sexual Medicine, 2015 INTRODUCTION Pessaries are commonly used to treat pelvic floor disorders, but little is known about the sexual function of pessary users. AIM We aimed to describe sexual function among pessary users and pessary management with regard to sexual activity.
K. Meriwether +5 more
semanticscholar +1 more source
Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim +4 more
wiley +1 more source
Overactive Bladder Syndrome Treatments and Their Effect on Female Sexual Function: A Review
Sexual Medicine, 2020 Introduction: Overactive bladder (OAB), the most common subtype of urinary incontinence, has a heavy price on quality of life, especially on sexual life.
Gali Levy, MD, Lior Lowenstein, MD
doaj