Results 61 to 70 of about 64,387 (299)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Correlation of Sexual Maturation with Skeletal Age of Southern Chinese Girls
Australasian Orthodontic Journal, 1997 The correlation of skeletal maturation with the chronological ages of the onset of f our secondary sexual characteristics (menarche, appearance of pubic hair and axillary hair, and breast development) was studied in a group of 117 Southern Chinese girls ...
So Lisa L.Y.
doaj +1 more source
, 2011 Sexual maturation of Atlantic cod, Gadus morhua, is a major problem during commercial on growing as fish divert energy away from growth into gonadal development. While the photoperiod regimes that inhibit maturation are well described, when manipulations
A. Davie +5 more
core +1 more source
Evo-devo of human adolescence: beyond disease models of early puberty [PDF]
, 2013 Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
Belsky, Jay +4 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Growth and Pubertal Development in Children With Sickle Cell Anaemia at Muhimbili National Hospital 2010 [PDF]
, 2011 Sickle cell anaemia (SCA) is a genetic disorder with multisystem manifestations. Paediatricians and general practitioners dealing with these patients need to know the overview of the genetics, diagnosis, clinical manifestations, and treatment of sickle ...
Jacob, Theopista
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Gut microbiota regulates the brain metabolism of sexually mature drones
Microbiology SpectrumPrevious studies have found that gut microbiota and metabolites may be crucial in insect sexual maturation. For example, during sexual maturity, the increased dopamine in the drone’s brain can affect its reproductive behavior, such as flight, mating, and
Jun Zhang +12 more
doaj +1 more source
Methodological and ethical aspects of the sexual maturation assessment in adolescents
Revista Paulista de Pediatria, 2013 OBJECTIVE To analyze methodological and ethical aspects in the sexual maturation assessment of adolescents. DATA SOURCES Books and theses, articles and legislations on the Medline, SciELO, Science Direct databases, besides institutional documents of the ...
Eliane Rodrigues de Faria +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source