Results 171 to 180 of about 247,698 (307)

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Consensual Non-Monogamy (CNM) - Considering Sexual Minorities and Moving Away from a Dyadic Conceptualization. [PDF]

Int J Sex Health
Morar-Bolba D, Banse R, Conley TD.
europepmc   +1 more source

Thwarted Belonging Needs: A Mechanism Prospectively Linking Multiple Levels of Stigma and Interpersonal Outcomes among Sexual Minorities. [PDF]

J Soc Issues, 2023
Lattanner MR, Hatzenbuehler M.
europepmc   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Intravenous Methamphetamine Use, HIV Status and PrEP Uptake Among a U.S. Sample of 29,880 Gender and Sexual Minorities, 2022-2023. [PDF]

AIDS Behav
Bartholomew TS, Plesons M, Westmoreland DA, D'Angelo AB, Mirzayi CA, Dearolf M, Guo Y, Hoeppner E, Richards NS, Patel VV, Nash D, Carrico AW, Grov C.   +12 more
europepmc   +1 more source

Do psychosocial factors mediate sexual minorities' risky sexual behaviour? A twin study. [PDF]

Health Psychol, 2022
Oginni OA, Jern P, Rahman Q, Rijsdijk FV.   +3 more
europepmc   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Recommendations for promoting affirming healthcare for gender and sexual minorities with intersecting marginalized identities. [PDF]

BMC Health Serv Res
Singh RS, Zamarin K, Eckstrand KL, Sklar M, Sturm R, Willging C.   +5 more
europepmc   +1 more source

Cigarette Smoking and the Role of Menthol in Tobacco Use Inequalities for Sexual Minorities. [PDF]

Nicotine Tob Res, 2021
Ganz O, Delnevo CD.
europepmc   +1 more source