Advanced Science, EarlyView.A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang +10 more
wiley +1 more source
Intravenous Methamphetamine Use, HIV Status and PrEP Uptake Among a U.S. Sample of 29,880 Gender and Sexual Minorities, 2022-2023. [PDF]
AIDS BehavBartholomew TS +12 more
europepmc +1 more source
Cigarette Smoking and the Role of Menthol in Tobacco Use Inequalities for Sexual Minorities. [PDF]
Nicotine Tob Res, 2021 Ganz O, Delnevo CD.
europepmc +1 more source
Advanced Science, EarlyView.This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian +8 more
wiley +1 more source
An ignored minority status: Consequences for sexual minorities living in a biased society. [PDF]
Soc Personal Psychol Compass, 2021 Trujillo MA, Mendes WB.
europepmc +1 more source
Advanced Science, EarlyView.Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang +15 more
wiley +1 more source
The Association Between Marijuana Use and Myocardial Infarction, Asthma, and Depression in Racial and Sexual Minorities: BRFSS 2016-2022. [PDF]
AJPM FocusWillmott HR, Chen S.
europepmc +1 more source
A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment
Advanced Science, EarlyView.MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu +15 more
wiley +1 more source
Exploring Self-Reported Effects of Naturalistic Psychedelic Use Among Gender and Sexual Minorities: A Quantitative Survey Study. [PDF]
J Psychoactive DrugsLancelotta R +9 more
europepmc +1 more source
ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma
Advanced Science, EarlyView.MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang +5 more
wiley +1 more source