Results 111 to 120 of about 2,105,134 (400)

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan   +10 more
wiley   +1 more source

New Hampshire Public Library Services for Survivors of Domestic and Sexual Violence

open access: yesIn the Library with the Lead Pipe, 2019
In Brief Domestic violence and sexual assault survivors experience unique information needs that can be answered through formal avenues such as a crisis center or police/court proceedings, but many survivors do not take a formal route to recovery.
Miranda Dube
doaj  

Sexual violence and pregnancy-related physical symptoms

open access: yesBMC Pregnancy and Childbirth, 2012
Background Few studies have investigated the impact of sexual violence on health during pregnancy. We examined the association between sexual violence and the reporting of physical symptoms during pregnancy.
Lukasse Mirjam   +3 more
doaj   +1 more source

Intimate Partner Violence and Sexual Violence in the Fairbanks North Star Borough: Key Results from the 2011 Alaska Victimization Survey [PDF]

open access: yes, 2011
This document is a two-page summary of the key results from the 2011 Alaska Victimization Survey for the Fairbanks North Star Borough, which was conducted from April to June 2011, with results released on October 7, 2011 in Fairbanks. Findings include:
Rosay, André B.
core   +1 more source

Commentary: Actions to end violence against women : a multi-sector approach [PDF]

open access: yes, 2015
Many forms of violence affect women and girls, such as physical and sexual abuse, trafficking, female genital mutilation, early and forced marriage, murders in the name of honour or dowry, and sexual harassment and abuse by authority figures.
García-Moreno, Claudia   +1 more
core   +4 more sources

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

open access: yesAdvanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao   +9 more
wiley   +1 more source

Hidden Violence: Preventing and Responding to Sexual Exploitation and Sexual Abuse of Adolescent Boys [PDF]

open access: yes, 2012
Boys and girls experience sexual violence and sexual exploitation in gender differentiated ways. Numerous national-level surveys have found that boys experience these forms of violence at lower rates than girls do, but at rates that nevertheless merit ...
Gary Barker, Piotr Pawlak
core  

Health services for survivors of gender-based violence in northern Uganda: a qualitative study.

open access: yes, 2008
The 20-year war in northern Uganda has resulted in up to 1.7 million people being internally displaced, and impoverishment and vulnerability to violence amongst the civilian population.
Borchert, Matthias   +4 more
core   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

open access: yesAdvanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou   +10 more
wiley   +1 more source

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