Results 111 to 120 of about 788,788 (345)
Legal Presentation for Children with Disabilities Victims of Sexual Violence in Sidoarjo Regency
, 2023 Perta Wida Subastian, Emy Rosnawati
openalex +1 more source
Advanced Science, EarlyView.This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley +1 more source
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
BMC Global and Public HealthBackground Sexual assault on college campuses is a major public health concern. Over half of incidents of sexual violence on college campuses occur in the context of victim or perpetrator alcohol use.
Elizabeth A. Walker +10 more
doaj +1 more source
Consensual Violence: A Cultural Contradiction
, 2015 In American culture, violence is typically understood as inherently negative; no one would want to be personally subjected to violence because violence by its very nature is undesirable. Thus, the idea of seeking out violence seems paradoxical.
Rivoli, Lisa R.
core
Intimate Partner Violence and Sexual Violence in the Yukon-Kuskokwim Delta: Key Results from the 2012 Alaska Victimization Survey [PDF]
, 2012 This document is a two-page summary of the key results from the 2012 Alaska Victimization Survey for the Yukon-Kuskokwim Delta of Alaska (Bethel Census Area and Kusilvak (formerly Wade Hampton) Census Area), which was conducted from March to May 2012 ...
Rosay, André B.
core
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source