Results 31 to 40 of about 16,290 (177)

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway

npj Breast Cancer, 2022
Breast cancer metastasis is the main cause of cancer death in women, so far, no effective treatment has inhibited breast cancer metastasis. Sulforaphane (SFN), a natural compound derived from broccoli, has shown potential health benefits in many cancers.
Ying Zhang, Qian Lu, Nan Li, Ming Xu, Tatsuo Miyamoto, Jing Liu   +5 more
doaj   +1 more source

SFN-mediated HO-1 induction in HCV replicon cells.

, 2016
(A) HO-1 promoter activity was assessed in SFN-treated HCV replicon cells. The HO-1 promoter reporter vector, pHO-1-Luc, was transfected into Huh-7 and Ava5 cells.
Chin-Kai Tseng (276730), Jin-Ching Lee (276734), Chun-Kuang Lin (276731), Wei-Chun Chen (276732), Jung-Sheng Yu (3214659), Yen-Hsu Chen (314564), Yao-Chin Hsu (276733)   +6 more
core   +1 more source

Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling

Cell Death and Disease, 2023
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Sulforaphane (SFN) has been shown to have anti-inflammatory and antioxidant properties.
Chujun Ma, Chaode Gu, Panpan Lian, Junaid Wazir, Renwei Lu, Binjia Ruan, Lulu Wei, Li Li, Wenyuan Pu, Ziqi Peng, Wentong Wang, Yangyongyi Zong, Zhiqiang Huang, Hongwei Wang, Yan Lu, Zhonglan Su   +15 more
doaj   +1 more source

Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway

Ecotoxicology and Environmental Safety, 2023
Sulforaphane (SFN), a bioactive phytocompound extracted from cruciferous plants, has received increasing attention due to its vital cytoprotective role in eliminating oxidative free radical through activation of nuclear factor erythroid 2-related factor (
Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang   +9 more
doaj   +1 more source

Separating Hydrogen Evolution From Electroplating in Zn Metal Batteries Using Scanning Electrochemical Microscopy

Advanced Energy Materials, EarlyView.
Operando SECM decouples hydrogen evolution from other degradation pathways in Zn metal batteries by quantifying its contribution during Zn electrodeposition. Although HER is shown to account for only a minor fraction of the irreversible charge loss, it remains a key indicator of interfacial evolution and by‐product formation governing cycling ...
J. T. Simon, Anna B. Gunnarsdóttir, Esther Lilian Gray, Debashis Tripathy, Farheen N Sayed, Manish Chhowalla, Stuart M. Clarke, Clare P. Grey, Svetlana Menkin   +8 more
wiley   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source

Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane

Foods, 2022
Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and
Xiude Li, Yihan Wang, Guoping Zhao, Guangmin Liu, Pengjie Wang, Jinwang Li   +5 more
doaj   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Sulforaphane-Enriched Extracts from Broccoli Exhibit Antimicrobial Activity against Plant Pathogens, Promising a Natural Antimicrobial Agent for Crop Protection

Biomolecules
Sulforaphane (SFN) is one of the hydrolysates of glucosinolates (GSLs), primarily derived from Brassica vegetables like broccoli. In clinical therapy, SFN has been proven to display antimicrobial, anticancer, antioxidant, and anti-inflammatory properties.
Lixia He, Hanmin Jiang, Yaotong Li, Xu Zhang, Wenting Sun, Ce Liu, Zekai Zhao, Chengrong Yun, Hui Li, Chunguo Wang   +9 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source