Results 41 to 50 of about 9,667 (179)

Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2

Communications Biology, 2023
Selenoprotein P (SeP) is a major selenoprotein in serum predominantly produced in the liver. Excess SeP impairs insulin secretion from the pancreas and insulin sensitivity in skeletal muscle, thus inhibition of SeP could be a therapeutic strategy for ...
Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito   +7 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Investigation of magnesium aluminometasilicate (Neusilin US2) based surface solid dispersion of sorafenib tosylate using QbD approach: In vitro and in vivo pharmacokinetic study

ADMET and DMPK
Background and purpose: Sorafenib tosylate (SFN), a potent multikinase inhibitor, is used for the treatment of various cancers. However, it shows limited therapeutic applications due to its poor biopharmaceutical properties.
Bijoy Kumar Panda, Bothiraja Chellampillai, Sharad Ghodke, Ashwin Mali, Ravindra Kamble   +4 more
doaj   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

The State of the Art in Visualization Literacy

Computer Graphics Forum, EarlyView.
In this survey paper, we review 385 visualization literacy papers to understand the state of the field. We discuss 5 different types of research contributions, as well as 4 competency themes that capture the skills relevant to visualization literacy. Abstract Research in visualization literacy explores the skills required to engage with visualizations.
Matthew Varona, Karen Bonilla, Maryam Hedayati, Alark Joshi, Matthew Kay, Lane Harrison, Carolina Nobre   +6 more
wiley   +1 more source

Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. [PDF]

PLoS ONE, 2012
Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. Since prostaglandin E2 (PGE2) promotes cancer progression, we hypothesized that SFN may block PGE2 synthesis in cancer cells.
Jiping Zhou, Denise G Joplin, Janet V Cross, Dennis J Templeton   +3 more
doaj   +1 more source

Blue Light Enhances Health-Promoting Sulforaphane Accumulation in Broccoli (Brassica oleracea var. italica) Sprouts through Inhibiting Salicylic Acid Synthesis

Plants, 2023
As a vegetable with high nutritional value, broccoli (Brassica oleracea var. italica) is rich in vitamins, antioxidants and anti-cancer compounds. Glucosinolates (GLs) are one of the important functional components widely found in cruciferous vegetables,
Youyou Guo, Chunyan Gong, Beier Cao, Tiantian Di, Xinxin Xu, Jingran Dong, Keying Zhao, Kai Gao, Nana Su   +8 more
doaj   +1 more source

Relationship Between Self‐Reported Bruxism and Perceived Stress Among Brazilian Health Science Students

European Journal of Dental Education, EarlyView.
ABSTRACT Objectives Investigate the relationship between perceived stress and self‐reported bruxism among health science students, as well as to map the instruments used to assess both variables. Methods A total of 545 students from health science programs at the UNIFAL‐MG participated in this cross‐sectional study, which used the Self‐Reported Bruxism
Lizandra Oliveira Cunha, Mariana Martins de Vitro, Ihanael Ifanger, François Isnaldo Dias Caldeira, Allan Saj Porcacchia, Heloisa de Sousa Gomes, Nilton Jóse da Silva‐Filho, Ticiana Sidorenko de Oliveira Capote, Larissa Santana Rodriguez, Diego Girotto Bussaneli   +9 more
wiley   +1 more source