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Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development

Viruses
SFTSV is an emerging tick-borne virus causing hemorrhagic fever with a case fatality rate (CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread of the vector tick to more than 20 states in the United States, the SFTSV outbreak is a globally growing public health concern.
Dokyun Kim, Jae U Jung
exaly   +4 more sources

Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV

Nature Communications
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has high mortality rates and poses a significant threat to public health. To identify potential therapeutic targets against SFTSV, we conduct genome-wide knockout screening, which identifies the previously known host factor CCR2,
yan Liu
exaly   +4 more sources

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Errors in the deposited SFTSV L protein structure

Nature Microbiology, 2021
Stephen Cusack, Maria Rosenthal
openaire   +2 more sources

Circulation of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Nature: Transmission of SFTSV Between Mammals and Ticks

2019
Severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS virus (SFTSV), a novel phlebovirus, was reported to be endemic to central and northeastern China, South Korea, and Japan. SFTS is a tick-borne viral infection with high morbidity and mortality. SFTSV is circulating in nature in the SFTS-endemic areas.
openaire   +1 more source

Reply to: Errors in the deposited SFTSV L protein structure

Nature Microbiology, 2021
Panpan Wang, Lu Liu, Aijun Liu, Zhiyong Lou   +3 more
openaire   +2 more sources

[Inclusion Bodies are Formed in SFTSV-infected Human Macrophages].

Bing du xue bao = Chinese journal of virology, 2016
The severe fever with thrombocytopenia syndrome virus (SFTSV) is a new member in the genus Phlebovirus of the family Bunyaviridae identified in China. The SFTSV is also the causative pathogen of an emerging infectious disease: severe fever with thrombocytopenia syndrome.
Cong, Jin, Jingdong, Song, Ying, Han, Chuan, Li, Peihong, Qiu, Mifang, Liang   +5 more
openaire   +1 more source

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

Autophagy, 2022
Chuan-min Zhou
exaly  

SFTSV vaccine development Review article

2023
openaire   +1 more source

The SFTSV Nonstructural Proteins Induce Autophagy to Promote Viral Replication via Interaction with Vimentin

Journal of Virology, 2023
Zhuozhuang Lu, Zhiyun Wang, Tao Wang
exaly  

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

Cell Reports, 2020
Hao Li, Xiao-Ai Zhang, Xiao-Kun Li
exaly