Results 91 to 100 of about 9,424 (215)

Die Rolle von Protein Kinasen bei der Regulation des Natrium/D-Glukose Kotransporters (SGLT1)

, 2007
In der vorliegenden Arbeit wurde der Effekt von Proteinphosphorylierung auf die Funktion und Konformation des Natrium/D-Glucose Cotransporter 1 (SGLT1) untersucht.
Subramanian, Supriya (M. Sc.)
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, Volume 20, Issue 11, Page 2741-2763, November 2026.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Transcription and expression of SGLT1, GLUT2, and GLUT5.

, 2015
(d) Transcription of sglt1 was increased in low, medium, and high dose groups compared with the control group. Transcription of glut2 (e) and glut5 (f) did not changed after TAC administration.
Ningning He (829669), Yaohui Zhang (829668), Hao Chen (5190), Yan Wang (15435), Shusen Zheng (187083), Zhiwei Li (131853), Hui Chen (28597), Fei Sun (102854), Penghong Song (406225), Sheng Yan (339585)   +9 more
core   +1 more source

Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus

, 2023
Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) represents a new class of pharmacotherapy for type 2 diabetes mellitus, a major global health issue with an increasing social and economic burden.
Cui, Haigang, Liu, Johnson J, Haigang Cui, Chen, Mingwei, Johnson J. Liu, Lu, Jun, Luo, Xin, Xin Luo, Mingwei Chen, Jun Lu   +9 more
core   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

A biophysical glance at the outer surface of the membrane transporter SGLT1

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Proteins mediating the transport of solutes across the cell membrane control the intracellular conditions in which life can occur. Because of the particular arrangement of spanning a lipid bilayer and the many conformations required for their function, transport proteins pose significant obstacles for the investigation of their structure-function ...
Tyagi, N., Puntheeranurak, T., Raja, M., Kumar, A., Wimmer, B., Neundlinger, I., Gruber, H., Hinterdorfer, P., Kinne, R.   +8 more
openaire   +3 more sources

Electrogenic transport of amino acids and glucose differs between jejunum and ileum of female and castrated male finishing pigs

Italian Journal of Animal Science
It has been shown that the jejunum represents the most important site for the nutrient’s absorption in several species. However, in pigs, this information seems to be controversial and limited information are available about differences in intestinal ...
Marco Tretola, Giuseppe Bee, Paolo Silacci   +2 more
doaj   +1 more source

Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis.

PLoS ONE, 2019
Respiratory infection can be exacerbated by the high glucose concentration in the airway surface liquid (ASL). We investigated the effects of salbutamol and phlorizin on the pulmonary function, oxidative stress levels and SGLT1 activity in lung ...
Léia Cardoso-Sousa, Emilia Maria Gomes Aguiar, Douglas Carvalho Caixeta, Danielle Diniz Vilela, Danilo Pereira da Costa, Tamires Lopes Silva, Thúlio Marquez Cunha, Paulo Rogério Faria, Foued Salmen Espindola, Ana Carolina Jardim, Alexandre Antônio Vieira, Tales Lyra Oliveira, Luiz Ricardo Goulart, Robinson Sabino-Silva   +13 more
doaj   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source

How the Sea Salt Chocolate Cookie Became a Thing: The Role of Flavor Pairing in Obesity

Obesity, Volume 34, Issue 11, Page 2016-2019, November 2026.
Proposed framework illustrating how flavor pairing and multisensory flavor architecture may sustain hedonic eating through enhanced palatability, reward preservation, delayed sensory‐specific satiety, and post‐ingestive signaling, thereby promoting excess energy intake and obesity risk.
Mohammed Ayyad, Eugene Kim
wiley   +1 more source