Results 71 to 80 of about 9,424 (215)
Cellular distribution and regulation of intestinal SGLT1 [PDF]
, 2011 Diabetes is achieving epidemic proportions in many countries. In addiction to high blood glucose it is associated with increased intestinal expression of the sodium-glucose cotransporter (SGLT1). This transporter is located in brush-border membrane (BBM)
Sá, Carla M. +3 more
core +1 more source
The journey from gene knockout to clinical medicine: telotristat and sotagliflozin
Drug Design, Development and Therapy, 2019 Marc S Rendell1,2 1Association of Diabetes Investigators, Omaha, NE 68131, USA; 2Rose Salter Medical Research Foundation, Newport Coast, CA 92657, USA Abstract: Gene knockout has been a powerful technique to evaluate the physiologic role of selected ...
Rendell MS
doaj
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source
Six-state model of the sodium/glucose co-transporter SGLT1.
, 2015 Six-state model of the sodium/glucose co-transporter SGLT1.
Morten Gram Pedersen (505334) +1 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim To evaluate the acute effects of acarbose and canagliflozin, alone and in combination, on postprandial total GLP‐1 and glycaemic responses during a mixed meal test in adults with post‐bariatric hypoglycaemia (PBH). Materials and Methods This single‐centre, randomised, four‐period crossover physiological study included 12 adults with PBH ...
Wei Yang +11 more
wiley +1 more source
Bridging the gap between structure and kinetics of human SGLT1 [PDF]
American Journal of Physiology-Cell Physiology, 2012 The Na+-glucose cotransporter hSGLT1 is a member of a class of membrane proteins that harness Na+ electrochemical gradients to drive uphill solute transport. Although hSGLT1 belongs to one gene family (SLC5), recent structural studies of bacterial Na+ cotransporters have shown that Na+ transporters in different gene families have the same structural ...
Sala-Rabanal, Monica +5 more
openaire +3 more sources
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Dietary components that influence appetite‐related hormones and subjective satiety may help regulate food intake. Aqueous carob (Ceratonia siliqua L.) preparations may have a role in postprandial appetite regulation. Aims To investigate the effects of an aqueous carob preparation incorporated into a high‐fat meal on postprandial ...
Charalampia Amerikanou +5 more
wiley +1 more source
A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. [PDF]
PLoS ONE, 2010 Sodium-glucose cotransporter proteins (SGLT) belong to the SLC5A family, characterized by the cotransport of Na(+) with solute. SGLT1 is responsible for intestinal glucose absorption.
Laura Bianchi, Ana Díez-Sampedro
doaj +1 more source
Contribution of SGLT1 in cardiac glucose uptake
Archives of Cardiovascular Diseases Supplements, 2018 Introduction The sodium-glucose transporter 1 (SGLT1) has been identified as the major SGLT isoform expressed in the heart. The exact role of this transporter in the heart is still unknown. Several authors have postulated a role on glucose transport using phlorizin as a specific inhibitor of SGLT transporters. However, high concentrations of phlorizin
L. Ferté +7 more
openaire +1 more source
Effect of LEFTY2 on SGLT1 transcript levels and protein abundance.
, 2020 A. Arithmetic means ± SEM (n = 4) of SGLT1 transcript levels from Ishikawa cells without (black) or with treatment (purple) with 25 ng/ml LEFTY2 for 48 hours. L19 was used as a housekeeping control. B.
Ni Zeng (797786) +12 more
core +1 more source