Results 81 to 90 of about 9,424 (215)

Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2 [PDF]

, 2019
Selective analogs of the natural glycoside phloridzin are marketed drugs that reduce hyperglycemia in diabetes by inhibiting the active sodium glucose cotransporter SGLT2 in the kidneys.
van der Pijl, Pieter, Marian Geldof, Vanpaeschen, T., Bruyn, T. de, van Westen, Gerard J.P., Johan Nicolaï, Vanpaeschen, Toon, Gouka, R., Westen, G.J.P. van, Lindsey Burggraaff, Vermeer, M., Burggraaff, L., Toon Vanpaeschen, Burggraaff, Lindsey, de Roo, Niels, de Bruyn, Tom, Oranje, P., Annaert, Pieter, Pijl, P. van der, Chalet, C., Annaert, P., Guus Duchateau, Niels de Roo, IJzerman, A.P., Geldof, Marian, Duchateau, Guus, Mario Vermeer, Robin Gouka, Gouka, Robin, Clauwaert, Fenja, Gerard J. P. van Westen, Nicolai, Johan, Geldof, M., Tom de Bruyn, Vermeer, Mario, Clément Chalet, Nicolai, J., Chalet, Clement, Fenja Clauwaert, Oranje, Paul, Duchateau, G., Clauwaert, F., Paul Oranje, IJzerman, Adriaan P., Roo, N. de, Pieter van der Pijl, Pieter Annaert, Adriaan P. IJzerman   +47 more
core   +1 more source

The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Regulates the Na-Glucose Transporter SGLT1 in Intestinal Epithelial Cells

Cells
Obesity is a complex chronic inflammatory condition that results from excess fat accumulation. It increases the risk of developing numerous co-morbidities such as Type 2 diabetes mellitus, cardiovascular disease, hypertension, and stroke.
Vivian Naa Amua Wellington, Soudamani Singh   +1 more
doaj   +1 more source

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Zachary Bloomgarden
wiley   +1 more source

LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells.

PLoS ONE, 2020
LEFTY2 (endometrial bleeding associated factor; EBAF or LEFTYA), a cytokine released shortly before menstrual bleeding, is a negative regulator of cell proliferation and tumour growth.
Ni Zeng, Toshiyuki Okumura, Md Alauddin, Shayan Khozooei, Janet Rajaxavier, Shaqiu Zhang, Yogesh Singh, Bing Shi, Sara Y Brucker, Diethelm Wallwiener, Satoru Takeda, Florian Lang, Madhuri S Salker   +12 more
doaj   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan Chandrahasa Shetty, Sujina Simon Sailet   +3 more
wiley   +1 more source

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs

, 2021
The tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) have been widely used for non-small cell lung cancer (NSCLC) patients, but the development of acquired resistance remains a therapeutic hurdle.
Yihua Wang, Hsiao, Yu-Chun, Wu, Chun-Yi, Bo-Wei Wang, Chun-Yi Wu, Zhang Weihua, Hung, Mien-Chie, Chih-Hsin Tang, Chia-Hung Chen, Ruey-Hwang Chou, Chen, Chia-Hung, Chen, Yun-Ju, Yun-Ju Chen, Chen, Chih-Yi, Wei-Chien Huang, Fang-Ju Cheng, Wang, Bo-Wei, Mien-Chie Hung, Wei, Ya-Ling, Chou, Ruey-Hwang, Tu, Chih-Yen, Chih-Yen Tu, Wang, Yihua, Ya-Ling Wei, Te-Chun Hsia, Tang, Chih-Hsin, Yu-Chun Hsiao, Hsia, Te-Chun, Jennifer L. Hsu, Weihua, Zhang, Huang, Wei-Chien, Chih-Yi Chen, Cheng, Fang-Ju, Hsu, Jennifer   +33 more
core   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

From Food Waste to Phytochemicals: Green Recovery, Food‐Matrix Applications, and Metabolic‐Health Translation of Residue‐Derived Polyphenols

Phytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
Decision rule: The lowest‐scoring gate determines overall readiness. Suggested concise take‐home message: Residue‐derived polyphenols should advance from chemically defined sources through food‐grade recovery and real‐matrix validation to realistic exposure‐based health evidence.
Chandan Kumar Sahu, Syed Irshaan, S. Karthikeyan   +2 more
wiley   +1 more source