Results 21 to 30 of about 9,424 (215)

SGLT1 does compensate for SGLT2 inhibition [PDF]

European Heart Journal - Cardiovascular Pharmacotherapy, 2016
A correction has been published: European Heart Journal - Cardiovascular Pharmacotherapy, Volume 4, Issue 2, April 2018, Page 101, https://doi.org/10.1093/ehjcvp ...
Martinez-Martin, Francisco Javier, Jimenez-Martin, Natalia, Sablon-Gonzalez, Nery   +2 more
openaire   +3 more sources

SGLT1/2 as the potential biomarkers of renal damage under Apoe−/− and chronic stress via the BP neural network model and support vector machine

Frontiers in Cardiovascular Medicine, 2022
BackgroundChronic stress (CS) could produce negative emotions. The molecular mechanism of SGLT1 and SGLT2 in kidney injury caused by chronic stress combined with atherosclerosis remains unclear.MethodsIn total, 60 C57BL/6J mice were randomly divided into
Gai-feng Hu, Gai-feng Hu, Gai-feng Hu, Xiang Wang, Xiang Wang, Ling-bing Meng, Ling-bing Meng, Jian-yi Li, Jian-yi Li, Hong-xuan Xu, Di-shan Wu, Di-shan Wu, Meng-jie Shan, Meng-jie Shan, Yu-hui Chen, Jia-pei Xu, Tao Gong, Zuoguan Chen, Yong-jun Li, De-ping Liu, De-ping Liu   +20 more
doaj   +1 more source

Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes [PDF]

, 1992
Glucose uptake by rabbit intestine has been shown to be confined to the upper two-thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)-glucose linked transporter (SGLT1).
Turvey, A, Freeman, T C, MW Smith, Smith, M W, A Turvey, TC Freeman   +5 more
core   +1 more source

Characterization of left ventricular myocardial sodium-glucose cotransporter 1 expression in patients with end-stage heart failure

Cardiovascular Diabetology, 2020
Background Whereas selective sodium-glucose cotransporter 2 (SGLT2) inhibitors consistently showed cardiovascular protective effects in large outcome trials independent of the presence of type 2 diabetes mellitus (T2DM), the cardiovascular effects of ...
Alex Ali Sayour, Attila Oláh, Mihály Ruppert, Bálint András Barta, Eszter Mária Horváth, Kálmán Benke, Miklós Pólos, István Hartyánszky, Béla Merkely, Tamás Radovits   +9 more
doaj   +1 more source

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice

Cellular Physiology and Biochemistry, 2017
Background: Cellular glucose uptake may involve either non-concentrative glucose carriers of the GLUT family or Na+-coupled glucose-carrier SGLT1, which accumulates glucose against glucose gradients and may thus accomplish cellular glucose uptake even at
Piyush Sharma, Vishal Khairnar, Ivana Vrhovac Madunić, Yogesh Singh, Aleksandra Pandyra, Madhuri S. Salker, Hermann Koepsell, Ivan Sabolić, Florian Lang, Philipp A. Lang, Karl S. Lang   +10 more
doaj   +1 more source

MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival. [PDF]

PLoS ONE, 2013
MAP17 is a membrane-associated protein that is overexpressed in human tumors. Because the expression of MAP17 increases reactive oxygen species (ROS) generation through SGLT1 in cancer cells, in the present work, we investigated whether MAP17 and/or ...
Marco Perez, Juan M Praena-Fernandez, Blanca Felipe-Abrio, Maria A Lopez-Garcia, Antonio Lucena-Cacace, Angel Garcia, Matilde Lleonart, Guiovanna Roncador, Juan J Marin, Amancio Carnero   +9 more
doaj   +1 more source

Canagliflozin: from glycemic control to improvement of cardiovascular and renal prognosis in patients with type 2 diabetes mellitus. Resolution of Advisory Board

Сахарный диабет, 2022
Inhibitors of the sodium-glucose cotransporter type 2 (SGLT2i) are a modern class of antihyperglycemic drugs with an insulin-independent mechanism of action.
M. V. Shestakova, A. S. Ametov, M. B. Antsiferov, T. P. Bardymova, F. V. Valeeva, G. R. Galstyan, T. Yu. Demidova, I. A. Karpova, T. P. Kiseleva, A. Yu. Mayorov, A. M. Mkrtumyan, S. V. Nedogoda, N. А. Petunina, L. A. Ruyatkina, L. A. Suplotova, O. Yu. Sukhareva, V. V. Fadeev, M. S. Shamkhalova   +17 more
doaj   +1 more source

The Effect of Ferulic Acid-Grafted Chitosan (FA-g-CS) on the Transmembrane Transport of Anthocyanins by sGLT1 and GLUT2

Foods, 2022
This work aims to evaluate the effect of ferulic acid-grafted chitosan (FA-g-CS) on the interaction between anthocyanin (ANC) and sGLT1/GLUT2 and their functions in ANC transmembrane transport using Caco-2 cells.
Yi Ma, Xiaojiao Chen, Tiwei Diao, Yinjiang Leng, Xiaoqin Lai, Xin Wei   +5 more
doaj   +1 more source

Substrate specificity of a chimera made from Xenopus SGLT1-like protein and rabbit SGLT1

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
To characterize the sugar translocation pathway of Na(+)/glucose cotransporter type 1 (SGLT1), a chimera was made by substituting the extracellular loop between transmembrane domain (TM) 12 and TM13 of Xenopus SGLT1-like protein (xSGLT1L) with the homologous region of rabbit SGLT1. The chimera was expressed in Xenopus oocytes and its transport activity
Nagata, Katsumi, Hata, Yoshio
openaire   +2 more sources

Gliflozins position update in the treatment algorithms for patients with type 2 diabetes mellitus and chronic kidney disease: new pathogenetic mechanisms and data from subanalyses of the large randomised control trails

Сахарный диабет, 2022
The series of the cardiovascular outcome trails have demonstrated the nephroprotective properties of the gliflozins. Canagliflozin in the CREDENCE, which was the first study with a primary focus on the evaluation of the nephroprotective properties of ...
O. Y. Sukhareva, Z. T. Zuraeva, M. S. Shamhalova   +2 more
doaj   +1 more source