Results 31 to 40 of about 9,424 (215)

Changing the Landscape of Hypertension Management With SGLT2i

Southeastern European Medical Journal, 2022
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a newer class of drugs that have primarily been used in the treatment of type 2 diabetes. However, as new findings from clinical trials have become available, their indication has been expanded to ...
Ines Bilić Ćurčić, Vjera Ninčević, Silvija Canecki Varžić, Ivana Prpić Križevac, Jasminka Milas Ahić, Ivica Mihaljević   +5 more
doaj   +1 more source

Sleeve Gastrectomy Surgery Improves Glucose Metabolism by Downregulating the Intestinal Expression of Sodium–Glucose Cotransporter-3

Journal of Investigative Surgery, 2022
Aims Sleeve gastrectomy (SG) has been proven effective in the treatment of obesity and type 2 diabetes. We hypothesized that SGLT3 may play an important role in the mechanism of glucose control and weight loss after SG.
Yixing Ren, Zhiming Zhao, Guodong Zhao, Qu Liu, Zizheng Wang, Rong Liu   +5 more
doaj   +1 more source

Effect of photobiomodulation therapy on the regulation of glucose uptake by lymphocytes in diabetes mellitus (Review)

Біологічні студії, 2021
For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is vital to understand the regulatory mechanisms that control the work of glucose transporters. Lymphocytes are pivotal for mediation of immune and inflammatory
A. O. Maslakova, M. Ya. Liuta, N. O. Sybirna   +2 more
doaj   +1 more source

Inducible Nitric Oxide Regulates Brush Border Membrane Na-Glucose Co-transport, but Not Na:H Exchange via p38 MAP Kinase in Intestinal Epithelial Cells

Cells, 2018
During chronic intestinal inflammation in rabbit intestinal villus cells brush border membrane (BBM) Na-glucose co-transport (SGLT1), but not Na/H exchange (NHE3) is inhibited.
Palanikumar Manoharan, Shanmuga Sundaram, Soudamani Singh, Uma Sundaram   +3 more
doaj   +1 more source

Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus [PDF]

, 2016
IntroductionGlycemic control is important in diabetes mellitus to minimize the progression of the disease and the risk of potentially devastating complications.
Koepsell, Hermann, Onishi, Akira, Song, Panai, Vallon, Volker   +3 more
core   +1 more source

Left Ventricular SGLT1 Protein Expression Correlates with the Extent of Myocardial Nitro-Oxidative Stress in Rats with Pressure and Volume Overload-Induced Heart Failure

Antioxidants, 2021
Myocardial sodium-glucose cotransporter 1 (SGLT1) has been shown to be upregulated in humans with heart failure (HF) with or without diabetes. In vitro studies have linked SGLT1 to increased nitro-oxidative stress in cardiomyocytes.
Alex Ali Sayour, Mihály Ruppert, Attila Oláh, Kálmán Benke, Bálint András Barta, Eszter Zsáry, Haoran Ke, Eszter Mária Horváth, Béla Merkely, Tamás Radovits   +9 more
doaj   +1 more source

Gedunin attenuates streptozotocin-induced diabetic hepatopathy in rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To examine the hepatoprotective effects of gedunin in streptozotocin (STZ)-induced diabetic rats. Methods: Rats were divided into 4 groups: control, STZ, gedunin, and STZ+gedunin.
Suchismita Mazumdar, Thankamani M Marar, Jyoti M Patki   +2 more
doaj   +1 more source

Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Journal of Cheminformatics, 2019
Sodium-dependent glucose co-transporter 1 (SGLT1) is a solute carrier responsible for active glucose absorption. SGLT1 is present in both the renal tubules and small intestine.
Lindsey Burggraaff, Paul Oranje, Robin Gouka, Pieter van der Pijl, Marian Geldof, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +7 more
doaj   +1 more source

SGLT1 inhibition boon or bane for diabetes‐associated cardiomyopathy [PDF]

Fundamental & Clinical Pharmacology, 2019
AbstractChronic hyperglycaemia is a peculiar feature of diabetes mellitus (DM). Sequential metabolic abnormalities accompanying glucotoxicity are some of its implications. Glucotoxicity most likely corresponds to the vascular intricacy and metabolic alterations, such as increased oxidation of free fatty acids and reduced glucose oxidation.
Jaspreet Kalra, Suresh Babu Mangali, Deepika Dasari, Audesh Bhat, Srashti Goyal, Indu Dhar, Dharamrajan Sriram, Arti Dhar   +7 more
openaire   +4 more sources

SGLT1 is located in the apical membrane.

, 2014
Jejunal samples from sglt1+/+ mice before and after glucose gavage, respectively, as well as from and sglt1−/− littermates were stained for SGLT1 (red). Nuclei were stained with DAPI (blue). Apical localization of SGLT1 in sglt1+/+ mice (A) before and (B)
Kerstin E. Geillinger (527573), Pia V. Röder (527572), Tamara S. Zietek (527574), Hermann Koepsell (242439), Bernard Thorens (120953), Hannelore Daniel (198670)   +5 more
core   +1 more source