Results 201 to 210 of about 54,917 (299)

Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin‐induced diabetic mice

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Oxidative stress is thought to play a role in the onset and progression of diabetic nephropathy (DN). Nuclear factor erythroid‐related factor 2 (Nrf2) is a master regulator of antioxidant and detoxification pathways and provides cellular protection against oxidative stress.
Suratsawadee Promsuwan, Yumi Takiyama, Takao Takiyama, Yuri Takiyama, Hiroya Kitsunai, Hiroshi Nomoto   +5 more
wiley   +1 more source

Medicare Part D formulary coverage of SGLT2 inhibitors across cardiovascular-kidney-metabolic indications, 2019-2026. [PDF]

Endocrine
Jain V, McCoy RG.
europepmc   +1 more source

A study of changes in insulin requirements related to the menstrual cycle in Japanese women with type 1 diabetes using the advanced hybrid closed‐loop system

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction In type 1 diabetes (T1D), insulin requirements and glycemic control may vary across the menstrual cycle. We examined phase‐related differences in insulin requirements, glycemic metrics, and recorded carbohydrate amounts in women using an advanced hybrid closed‐loop (AHCL) system and their associations with menstrual symptoms ...
Eri Takagi, Hideyoshi Kaga, Ryoki Mori, Shohei Fujikawa, Haruki Nagashima, Toshiki Kogai, Mami Koshibu, Junko Sato, Yuya Nishida, Fuki Ikeda, Yoshifumi Tamura, Hirotaka Watada   +11 more
wiley   +1 more source

C-Peptide Changes and Glycemic Response During DPP-4 Versus SGLT2 Inhibitor Therapy in Type 2 Diabetes: The Role of Baseline C-Peptide. [PDF]

Medicina (Kaunas)
Alişan İ, Akbal K, Yılmaz Ç, Dinçer C, Işık B, Mustan AG, Arıcı FN, Öztürk HA, Sümbül HE.   +8 more
europepmc   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

Real-World Pharmacological Patterns and Residual Cardiometabolic Risk in Patients with Type 2 Diabetes in Romania. [PDF]

Diseases
Petca BL, Popovici PA, Igna AD, Ghitea TC, Popoviciu MS.   +4 more
europepmc   +1 more source

Diabetes attenuates weight reduction‐mediated liver fibrosis regression in persons with morbid obesity

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims Weight loss by laparoscopic sleeve gastrectomy (LSG) compared to medical weight loss (low‐calorie diet: LCD) ameliorates diabetes and metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to evaluate changes in liver pathology 1‐year after LSG and their associations with metabolic factors in Japanese participants with
Daiki Matsubara, Yumie Takeshita, Masahiro Mori, Yujiro Nakano, Kenichi Harada, Noboru Takata, Kengo Hayashi, Hideki Moriyama, Noriyuki Inaki, Masao Honda, Taro Yamashita, Toshinari Takamura   +11 more
wiley   +1 more source

SGLT2 gene expression in thirst-promoting NOS1 neurons and vasopressin-synthesizing neurons in male rats. [PDF]

Physiol Rep
Masuda T, Yoshida M, Kim YC, Vallon V, Morishita Y, Nagata D, Onaka T.   +6 more
europepmc   +1 more source

History of gastrointestinal symptoms with other glucose‐lowering agents is associated with gastrointestinal adverse events after imeglimin initiation: A retrospective real‐world study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Imeglimin is an oral antidiabetic agent with a novel mechanism of action. Gastrointestinal (GI) adverse events (AEs) have been reported during imeglimin therapy. However, the factors associated with the occurrence of GI AEs have not been fully elucidated. This study aimed to investigate the incidence of GI AEs and the factors
Kodai Yoshida, Yukiko Onishi, Tetsuya Kubota, Yoko Yoshida, Tazu Tahara, Satoru Takase, Masahiko Iwamoto, Ryusuke Nakada, Hikaru Aita, Masato Kasuga   +9 more
wiley   +1 more source

Clinical and Biochemical Responses to SGLT2 (Sodium-Glucose Cotransporter-2) Inhibitors in Patients With Rheumatic Heart Disease and Heart Failure. [PDF]

Cureus
Asthana A, Buragohain D, Caleb Harris P, Shikoh A, Malviya A, Mishra A.   +5 more
europepmc   +1 more source