Results 171 to 180 of about 38,006 (217)

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2. [PDF]

J Clin Invest
Abdualkader AM, Li X, Yin Y, Bai C, Pourfarziani P, Guan J, Kwon S, Kim KH, Al Batran R.   +8 more
europepmc   +1 more source

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan Chandrahasa Shetty, Sujina Simon Sailet   +3 more
wiley   +1 more source

SGLT2 inhibitors and outcomes in the chronic Post-LVAD phase: a multicenter real-world cohort study. [PDF]

Front Pharmacol
Wu JY, Lee KW, Huang SC, Chang HY, Lin YM.   +4 more
europepmc   +1 more source

Clinical characteristics and disease progression of typical adult‐onset type 1 diabetes and insulin‐dependent latent autoimmune diabetes in adults

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims We investigated the characteristics of typical adult‐onset type 1 diabetes (T1D) and insulin‐dependent latent autoimmune diabetes in adults (LADA) in Thailand. Methods This retrospective chart review enrolled typical T1D and insulin‐dependent LADA patients diagnosed at age ≥30 years, and who were followed up at Siriraj Hospital, Thailand,
Chanoknan Luksameejaroenchai, Thanida Tangjarusritaratorn, Lukana Preechasuk   +2 more
wiley   +1 more source

SGLT2 inhibitors and bone health in CKD. [PDF]

Clin Kidney J
Haarhaus M.
europepmc   +1 more source

Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin‐induced diabetic mice

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Oxidative stress is thought to play a role in the onset and progression of diabetic nephropathy (DN). Nuclear factor erythroid‐related factor 2 (Nrf2) is a master regulator of antioxidant and detoxification pathways and provides cellular protection against oxidative stress.
Suratsawadee Promsuwan, Yumi Takiyama, Takao Takiyama, Yuri Takiyama, Hiroya Kitsunai, Hiroshi Nomoto   +5 more
wiley   +1 more source

Imaging and Hemodynamic Mechanisms of Cardiac Remodeling with SGLT2 Inhibitors Across Heart Failure Phenotypes: A Systematic Review. [PDF]

Biomedicines
Buzzi DE, Mateoc-Sîrb T, Ardelean S, Zavragiu AC, Zimbru EL, Muntean C, Andor M.   +6 more
europepmc   +1 more source

A study of changes in insulin requirements related to the menstrual cycle in Japanese women with type 1 diabetes using the advanced hybrid closed‐loop system

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction In type 1 diabetes (T1D), insulin requirements and glycemic control may vary across the menstrual cycle. We examined phase‐related differences in insulin requirements, glycemic metrics, and recorded carbohydrate amounts in women using an advanced hybrid closed‐loop (AHCL) system and their associations with menstrual symptoms ...
Eri Takagi, Hideyoshi Kaga, Ryoki Mori, Shohei Fujikawa, Haruki Nagashima, Toshiki Kogai, Mami Koshibu, Junko Sato, Yuya Nishida, Fuki Ikeda, Yoshifumi Tamura, Hirotaka Watada   +11 more
wiley   +1 more source

Mitochondrial-inflammatory coupling in HFpEF: an emerging mechanistic framework for understanding the cardioprotective effects of SGLT2 inhibitors. [PDF]

Front Cardiovasc Med
Youniszad MG, Deng Y.
europepmc   +1 more source