Results 181 to 190 of about 38,006 (217)

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

Research Progress of SGLT2 Inhibitors in the Treatment of Acute Heart Failure: A Narrative Review. [PDF]

Int J Gen Med
Wang X, Ning Y, Wang X, Li G, Wang X, Wu D.   +5 more
europepmc   +1 more source

Diabetes attenuates weight reduction‐mediated liver fibrosis regression in persons with morbid obesity

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims Weight loss by laparoscopic sleeve gastrectomy (LSG) compared to medical weight loss (low‐calorie diet: LCD) ameliorates diabetes and metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to evaluate changes in liver pathology 1‐year after LSG and their associations with metabolic factors in Japanese participants with
Daiki Matsubara, Yumie Takeshita, Masahiro Mori, Yujiro Nakano, Kenichi Harada, Noboru Takata, Kengo Hayashi, Hideki Moriyama, Noriyuki Inaki, Masao Honda, Taro Yamashita, Toshinari Takamura   +11 more
wiley   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real-Life Experience From a National Reference Network. [PDF]

Diabetes Obes Metab
Robert L, Belalem I, Vigouroux C, Dupuis H, Vantyghem MC, Simonson M, Nobecourt E, Mosbah H, Beliard S, Jellimann S, Janmaat S, Vatier C, Lamothe S.   +12 more
europepmc   +1 more source

High urine osmolality and elevated urine sodium predict early nonresponse to fluid restriction in patients with the syndrome of inappropriate antidiuresis

Journal of Internal Medicine, EarlyView.
Abstract Introduction Fluid restriction is the current first‐line therapy for hyponatremia induced by the syndrome of inappropriate antidiuresis (SIAD), yet up to 50% of patients do not achieve an adequate plasma sodium correction. Reported predictors of nonresponse include urine osmolality >500 mOsm/kg, the Furst ratio >1 [(UNa + UK)/(PNa)], urine ...
Michelle Patricia Müller, Laura Potasso, Ewout J. Hoorn, Julie Refardt, Mirjam Christ‐Crain, for the HIT study investigators   +5 more
wiley   +1 more source

Targeting metabolism to protect fertility and healthy pregnancy with SGLT2 inhibitors and GLP-1RAs. [PDF]

Curr Opin Physiol
Flanary SM, Yoshida K, Alejandro EU, Townsend D.   +3 more
europepmc   +1 more source

GLP‐1 receptor agonists and serious adverse events: Evidence, uncertainty and clinical implications

Journal of Internal Medicine, EarlyView.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists provide benefits in weight reduction, glycaemic control in Type 2 diabetes, and cardiovascular and renal outcomes. Their widespread use has given rise to concerns regarding rare but potentially serious adverse events.
Peter Ueda
wiley   +1 more source

Sustained Use of SGLT2 Inhibitors and Cardiovascular Outcomes in Older Adults: A Landmark Cohort Study. [PDF]

Diabetes Obes Metab
Noma H, Yamazaki H, Sunada H, Oda F, Maeda M, Fukuda H.   +5 more
europepmc   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

SGLT2 Inhibitors Promote Diabetic Wound Healing Via AMPK/AKT/mTORC1-Regulated Endothelial Angiogenesis. [PDF]

Arterioscler Thromb Vasc Biol
Bestepe F, Ghanem GF, Kelly C, Huseynli K, Richards DV, Barber R, Zamary A, Sahu P, Salehi P, Huggins GS, Icli B.   +10 more
europepmc   +1 more source