Results 131 to 140 of about 32,432 (238)

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Correction: Alpinetin pretreatment prevents lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting ferroptosis via the Nrf2/SLC7A11/GPX4 pathway. [PDF]

Sci Rep
Liu Y, Zhao J, Cong W, Liu T, Sha K.
europepmc   +1 more source

Effectiveness and Predictors of House Dust Mite Subcutaneous Immunotherapy in Polysensitised Patients With Allergic Rhinitis: A Multicentre Retrospective Study

Clinical &Experimental Allergy, EarlyView.
Single‐allergen dust mite subcutaneous immunotherapy achieved 68.8% perennial symptom response rate in polysensitised allergic rhinitis patients. High mould and dust mite sIgE levels predicted poor allergen immunotherapy response, which indicated allergen‐specific sIgE levels may help guide personalised allergen immunotherapy decisions.
Zhouxian Pan, Shengyang Yao, Lisha Li, Yongshi Yang, Wenchao Guan, Yin Wang, Xiaoshang Lou, Chuanhe Liu, Yanmin Bao, Shijie Zhuang, Li Sha, Ruonan Chai, Rongfei Zhu, Kai Guan   +13 more
wiley   +1 more source

‘The Heart of the Matter’: Grandparent Childcare in Contemporary Chinese Families

Children &Society, EarlyView.
ABSTRACT Grandparent childcare is an international phenomenon, especially within families with children under 3 years old. China is no exception, as shown by a number of quantitative studies. Less clear is our understanding of the actual childcare arrangements involved and how these are negotiated and sustained through the intergenerational ...
Jiatong Ling, Lorna Montgomery, John Pinkerton   +2 more
wiley   +1 more source

Rutin Stabilises β‐Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration

Cell Proliferation, EarlyView.
Rutin directly binds to GSK3β, stabilising β‐catenin and activating Wnt/β‐catenin signalling to drive hair cycle.
Yanyan Zhang, Yuanjie Zhu, Mengyu Jin, Jing Chen, Siqi Yuan, Minjia Yuan, Yuou Sha, Qingmei Liu, Wenyu Wu, Juan Wang, Xiaolei Ding   +10 more
wiley   +1 more source

Technical Refinements in Laparoscopic Transabdominal Preperitoneal Repair for Scrotal Hernia Using High Sac Transection and Internal Ring Closure. [PDF]

Cureus
Chen G, Sha Y, Xu G, Wang K, Hu Y.
europepmc   +1 more source

Thrombin Generation in Pediatric Haemophilia A Patients on Extended Half‐Life FVIII versus Non‐FVIII Therapies

Haemophilia, EarlyView.
ABSTRACT Introduction The therapeutic landscape for patients with haemophilia A (PwHA) is rapidly evolving with the introduction of extended half‐life FVIII (EHL‐FVIII) and non‐FVIII therapies that mimic FVIII, such as emicizumab (EMI). Monitoring non‐factor therapies in the laboratory poses challenges; however, the thrombin generation assay (TGA) can ...
Jessica Garcia, Sean G. Yates, Ravi Sarode, Guy Young, Ayesha Zia   +4 more
wiley   +1 more source

Sulfated Hyaluronan in Dermatology: What's New? Overview of Evidence in Specific Dermatological Diseases. [PDF]

Pharmaceutics
Pellacani G, Michelini S, Trovato F, Rallo A, Gemma G, Chello C, Pavan M, Guarise C, Passi AG.   +8 more
europepmc   +1 more source

Miners' Reward Elasticity and Stability of Competing Proof‐of‐Work Cryptocurrencies

International Economic Review, EarlyView.
ABSTRACT Proof‐of‐Work cryptocurrencies employ miners to sustain the system through algorithmic reward adjustments. We develop a stochastic model of the multicurrency mining and identify conditions for stable transaction speeds. Bitcoin's algorithm requires hash supply elasticity <$<$1 for stability, while ASERT remains stable for any elasticity and ...
Kohei Kawaguchi, Junpei Komiyama, Shunya Noda   +2 more
wiley   +1 more source

The Effect of Gua Sha Therapy on Pain in Parkinson’s Disease: a Randomized Controlled Trial

International Journal of General Medicine
Yu Chen Xu,1,* Qiu Qin Wang,1,* Meng Yuan Chen,1 Yu Jie Gao,1 Jia Yi Wang,1 Hao Tian Ge,1 Heng Weng,1 Ju Ping Chen,2 Gui Hua Xu1 1School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department ...
Xu YC, Wang QQ, Chen MY, Gao YJ, Wang JY, Ge HT, Weng H, Chen JP, Xu GH   +8 more
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