Results 81 to 90 of about 1,005,648 (347)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Disrupting shadow in the prothoracic gland induced larval development arrest in the fall armyworm Spodoptera frugiperda

Frontiers in Physiology
IntroductionThe juvenile hormone (JH) and 20-hydroxyecdysone (20E) are the central regulating hormones of insect development. The timing of their secretion usually leads to developmental transitions.MethodsThe developmental transitions were evaluated via
Mian-Zhi Wu, Mian-Zhi Wu, Shu-Ting Fan, Shu-Ting Fan, Yuan-Chen Zhang, Jin-Fang Tan, Jin-Fang Tan, Guan-Heng Zhu, Guan-Heng Zhu   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Reseña del libro: Mujeres en el Arte Popular : de promesas, traiciones, monstruos y celebridades, Bartra, Eli

Secuencia, 2009
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María J. Rodríguez-Shadow
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Las investigaciones recientes sobre la migración laboral femenina internacional

Ciencia Ergo Sum, 2008
El objetivo de este artículo es analizar las investigaciones que se han llevado a cabo, desde diversas disciplinas, sobre la migración laboral femenina internacional. Los estudios que se examinan han sido elaborados desde diversos campos disciplinarios:
María J. Rodríguez Shadow
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Airborne InSAR Interferometric Phase Analysis, Unwrapping Method, and Fast Implementation in Low Coherence Areas

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Due to synthetic aperture radar (SAR) imaging geometry and scattering characteristics, there are some low coherence areas in interferometric SAR (InSAR) data, such as shadow and water, where the interferometric phase is discontinuous.
Fangfang Li, Chibiao Ding, Yueting Zhang, Donghui Hu   +3 more
doaj   +1 more source

Shadows of Bonnor black dihole by chaotic lensing

, 2018
We have studied numerically the shadows of Bonnor black dihole through the technique of backward ray-tracing. The presence of magnetic dipole yields non-integrable photon motion, which affects sharply the shadow of the compact object.
Chen, Songbai, Jing, Jiliang, Wang, Mingzhi   +2 more
core   +1 more source

Moser’s shadow problem

L’Enseignement Mathématique, 2019
Moser's shadow problem asks to estimate the shadow function \mathfrak s_b(n) , which is the largest number such that for each bounded convex polyhedron P with
Lagarias, Jeffrey C., Luo, Yusheng, Padrol, Arnau   +2 more
openaire   +2 more sources