Results 71 to 80 of about 5,930 (247)

Timescapes of shadow education: patterns and forces in the temporal features of private supplementary tutoring

open access: yes, 2022
This paper employs the lenses of timescapes, themselves shaped by wider conceptions of time, to view evolving patterns of private supplementary tutoring around the world.
Bray, TM
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Learning English in the ‘shadow’: Patterns and implications of English private tutoring in Vietnam

open access: yesStudies in English Language and Education
Private tutoring has grown in prominence on a global scale. While research in this area has increased in recent decades, there remains a lack of focus on English private tutoring.
Lan Thi Huong Nguyen, Thao Vu
doaj   +1 more source

The Role of Shadow Education in Capital Transformation and Identity Reconstruction: A Systematic Review of Overseas Graduate Applicants [PDF]

open access: yesSHS Web of Conferences
Against the backdrop of globalization in higher education and elitism in overseas graduate student applications, the Western academic evaluation system dominates global admission rules.
Wang Simin
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Shadow Economy and Entrepreneurial Entry [PDF]

open access: yes
We analyze theoretically and empirically the impact of the shadow economy on entrepreneurial entry, utilising 1998-2005 individual-level Global Entrepreneurship Monitor data merged with macro level variables.
Mickiewicz, Tomasz, Estrin, Saul
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Shadow education in the Netherlands

open access: yes, 2021
In the Netherlands, as in many countries, there is a growing use of shadow education: fee-based, organized, out-of-school learning activities that provide students with instruction or guidance in school subjects. Its increasing prevalence raises questions about both its position and function: the position that shadow education occupies in the ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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