Results 81 to 90 of about 249,158 (301)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The shadow value of employer-provided training
, 2010 This paper adopts an equivalent income approach to calculate the economic value of training activities for workers. Using econometric regression analysis of individual self-reported job satisfaction (JS) and data from the European Community Household Panel dataset (ECHP), the paper shows that employer-provided training exerts a positive and significant
Budría, Santiago, Swedberg, Pablo
openaire +1 more source
Decentralization and the Shadow Economy: Oates Meets Allingham-Sandmo [PDF]
This paper studies the impact of decentralization on the shadow economy. We argue that decentralization may decrease the size of the shadow economy mainly through two transmission channels: (1) Decentralization enhancing public sector efficiency ...
Andreas Bühn +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
FOREIGN EXPERIENCE OF EMPLOYMENT REGULATION
Aktualʹnì Problemi Rozvitku Ekonomìki Regìonu, 2019 The article is devoted to the study of foreign experience in regulating employment, training and retraining of the workforce in the leading countries of the world, ensuring the employment of labor resources.
N. Kaziuka
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The potential of artificial intelligence in business
Путеводитель предпринимателяThe article examines the potential of artificial intelligence in entrepreneurial activity in the Russian economy at the present stage of its development in the context of modern challenges.
S. L. Sazanova, N. N. Karmanov
doaj +1 more source
Wage-setting in Belgium: Collective Autonomy under the Shadow of the Law
Italian Labour Law e-Journal, 2019 In this contribution, a brief outline of wage-setting in Belgium will be given. Wages will be contextualized as constituting an essential element of the employment relation.
Filip Dorssemont
doaj +1 more source
Small Businesses and the Shadow Economy [PDF]
This paper investigates causalities between small businesses and the shadow economy in ten New Member States of the European Union in the years 2000–2005. The transition from a centrally planned to a market economy, with deregulation and privatization of
Bojan Nastav, Štefan Bojnec
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