Results 91 to 100 of about 131,912 (319)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Ozone and aerosol optical depth retrievals using the ultraviolet multi-filter rotating shadow-band radiometer [PDF]

open access: yesAtmospheric Measurement Techniques
The ultraviolet multi-filter rotating shadow-band radiometer (UV-MFRSR) is a seven-channel radiometer with narrowband filters centered between wavelengths 300 and 368 nm.
J. Michalsky   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Virtual Audio - Three-Dimensional Audio in Virtual Environments [PDF]

open access: yes, 1996
Three-dimensional interactive audio has a variety ofpotential uses in human-machine interfaces. After lagging seriously behind the visual components, the importance of sound is now becoming increas-ingly accepted.
Adler, Daniel
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

An Automatic Morphological Attribute Building Extraction Approach for Satellite High Spatial Resolution Imagery

open access: yesRemote Sensing, 2019
A new morphological attribute building index (MABI) and shadow index (MASI) are proposed here for automatically extracting building features from very high-resolution (VHR) remote sensing satellite images.
Weixuan Ma   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Ionospheric responses to the 21 August 2017 solar eclipse by using data assimilation approach

open access: yesProgress in Earth and Planetary Science, 2019
Using the physics-based thermosphere-ionosphere model (NCAR-TIEGCM) with an ensemble Kalman filter, this study reports the first data assimilative analysis of the ionosphere responses to the solar eclipse on 21 August 2017.
Chia-Hung Chen   +2 more
doaj   +1 more source

Colour layering and colour constancy [PDF]

open access: yes, 2014
Loosely put, colour constancy for example occurs when you experience a partly shadowed wall to be uniformly coloured, or experience your favourite shirt to be the same colour both with and without sunglasses on.
Brown, Derek
core   +1 more source

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