Results 101 to 110 of about 842,482 (293)

Constraining Nonsingular Black Holes with a Minkowski Core via EHT Observations of M87* and Sgr A*

open access: yesUniverse
The Event Horizon Telescope (EHT) imaging of M87* and Sgr A* provides a unique opportunity to test spacetime geometries in the strong-field regime.
Ming-Xin Li   +3 more
doaj   +1 more source

Ionospheric responses to the 21 August 2017 solar eclipse by using data assimilation approach

open access: yesProgress in Earth and Planetary Science, 2019
Using the physics-based thermosphere-ionosphere model (NCAR-TIEGCM) with an ensemble Kalman filter, this study reports the first data assimilative analysis of the ionosphere responses to the solar eclipse on 21 August 2017.
Chia-Hung Chen   +2 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

open access: yesFEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto   +14 more
wiley   +1 more source

Is shadow banking really banking? [PDF]

open access: yes
To those who don't know, the term "shadow banking" probably has a negative connotation. This primer draws parallels between what has been termed the shadow banking sector and the traditional banking sector—showing that they are similar in many ways.Banks
Rajdeep Sengupta, Bryan J. Noeth
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Foreign Direct Investment and Shadow Economy: A Causality Analysis Using Panel Data [PDF]

open access: yes
The present paper investigates the link between the shadow economy and FDI using the Granger panel causality test. For that purpose we use the shadow economy and FDI data for 145 countries of five data points 1999/2000, 2001/2002, 2002/2003, 2003/2004 ...
Nikopour, Hesam   +3 more
core  

Improved Current Mode Biquadratic Shadow Universal Filte [PDF]

open access: yesInformacije MIDEM, 2022
D. Singh, S. K. Paul
doaj   +1 more source

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